An Update on the Role of Adipose Tissues in Psoriasis

被引：43
作者：
Wong, Yisheng [1 ]
Nakamizo, Satoshi [2 ]
Tan, Kahbing J. [2 ]
Kabashima, Kenji [2 ,3 ]
机构：
[1] Natl Skin Ctr, Singapore, Singapore
[2] ASTAR, Singapore Immunol Network, Skin Res Inst Singapore, Singapore, Singapore
[3] Kyoto Univ, Sch Med, Dept Dermatol, Kyoto, Japan
来源：
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
关键词：
obesity; psoriasis; adipose tissue-obesity; adipokine cytokines; adipocyte; macrophage-cell; leptin; PRO-INFLAMMATORY CYTOKINES; ADIPONECTIN LEVELS; OBESITY; LEPTIN; SEVERITY; RESISTIN; ADIPOCYTES; ADIPOKINES; WHITE; ACCUMULATION;
D O I：
10.3389/fimmu.2019.01507
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
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页数：7
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