Ammonia as Ultimate Amino Source in Synthesis of Primary Amines via Nickel-Promoted C-H Bond Amination

被引：36

作者：

Yu, Lin ^{[1
]}

Yang, Chan ^{[1
]}

Yu, Yongqi ^{[1
]}

Liu, Da ^{[1
]}

Hu, Liang ^{[1
]}

Xiao, Yuanjiu ^{[1
]}

Song, Ze-Nan ^{[1
]}

Tan, Ze ^{[1
]}

机构：

[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 14期

关键词：

COPPER-CATALYZED SYNTHESIS; ARYL CHLORIDES; AMIDATION; ARENES; ACTIVATION; C(SP(2))-H; DERIVATIVES; C(SP(3))-H; ARYLATION; ANILINES;

D O I：

10.1021/acs.orglett.9b01968

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct use of ammonia in transition-metal promoted C-H bond amination for the synthesis of primary amines is considered to be one of the major challenges in synthetic organic chemistry. Herein, we report that such transformation can be successfully achieved via nickel-promoted amination of inert arene C-H bonds with ammonia gas assisted by an 8-amino-quinoline directing group.

引用

页码：5634 / 5638

页数：5

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