Clinical and Therapeutic Implications of Cancer Stem Cells

被引：271

作者：

Clarke, Michael F. ^{[1
]}

机构：

[1] Stanford Univ, Stanford Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2019年 / 380卷 / 23期

关键词：

ACUTE MYELOID-LEUKEMIA; TGF-BETA; CLONAL HEMATOPOIESIS; MYELOGENOUS LEUKEMIA; SELF-RENEWAL; MUTATIONS; MAINTENANCE; CATENIN; GROWTH; IDENTIFICATION;

D O I：

10.1056/NEJMra1804280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cancers arise in tissues that can replicate and self-renew. Like normal tissues, cancers can replenish themselves, grow, and metastasize because of stem cells that are similar to normal stem cells but seem to respond less well to environmental stop signals in their niche. Therapy that targets cancer stem cells may be the next avenue of cancer treatment.

引用

页码：2237 / 2245

页数：9

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