Mean platelet volume in schizophrenia unaltered after 1 year of clozapine exposure

被引：16

作者：

Lee, Jimmy ^{[1
,2
,3
]}

Powell, Valerie ^{[3
]}

Remington, Gary ^{[3
,4
]}

机构：

[1] Inst Mental Hlth, Dept Gen Psychiat 1, Singapore, Singapore

[2] Duke NUS Grad Med Sch, Off Clin Sci, Singapore, Singapore

[3] Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON M5T 1R8, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

来源：

SCHIZOPHRENIA RESEARCH | 2014年 / 157卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

Cardiovascular; Acute myocardial infarction; Inflammation; Antipsychotics; SIZE;

D O I：

10.1016/j.schres.2014.04.038

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study investigated the MPV of patients with major psychoses before and after 1 year of clozapine exposure. Data were obtained from chart reviews of patients who were initiated on clozapine at the Centre of Addiction and Mental Health (CAMH) in Toronto. 100 patients were eligible for this study; 65 remained on clozapine after 1 year. Prior to clozapine initiation, MPV was 10.79 +/- 0.91 fL and there was no difference in MPV after 1 year of clozapine exposure (p = 0.777). We found high MPV in patients with schizophrenia and related psychoses, which was unaltered after 1 year of clozapine treatment. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：134 / 136

页数：3

共 15 条

[1] Platelet size: Measurement, physiology and vascular disease [J].