Casein/gelatin beads: I. Cross-linker solution composition effect on cross-linking degree

被引：14

作者：

Bulgarelli, E ^{[1
]}

Forni, F ^{[1
]}

Bernabei, MT ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Pharmaceut Sci, I-41100 Modena, Italy

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 190卷 / 02期

关键词：

casein/gelatin beads; cross-linking degree; d; l-glyceraldehyde;

D O I：

10.1016/S0378-5173(99)00262-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of the cross-linker solution composition (aqueous and organic ratio) on the cross-linking degree of hydrophilic casein/gelatin beads has been evaluated. Casein/gelatin beads with different radii have been prepared and treated over the same time with three different cross-linker solvent compositions containing d,l-glyceraldehyde at the same concentration. The cross-linking degree was studied not only comparing the results of swelling process and degradation rate, widely reported in literature as methods for the cross-linking degree evaluation, but also determining the solvent penetration rate and the d,l-glyceraldehyde reacting percentage. It has been observed, in fact, that the cross-linker solvent composition influences the penetration rate through the matrix of the cross-linker, thus controlling the homogeneity of the matrix cross-linking. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 182

页数：8