Diisopropylcarbodiimide: A novel reagent for the synthesis of 1,3,4-oxadiazoles on solid-phase

被引：0
作者：
Brown, BJ [1 ]
Clemens, IR [1 ]
Neesom, JK [1 ]
机构：
[1] Glaxo Wellcome Res & Dev Ltd, Enzyme Med Chem 1, Stevenage SG1 2NY, Herts, England
来源：
SYNLETT | 2000年 / 01期
关键词：
acylations; amides; cyclisations; heterocycles; solid-phase synthesis;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using diisopropylcarbodiimide (DIPCDI) in DMF to effect cyclodehydration, various resin bound 1,2-diacylhydrazines were converted to the corresponding 2,5-disubstituted 1,3,4-oxadiazoles in good yields and purities.
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收藏
页码：131 / 133
页数：3
相关论文
共 14 条
  • [1] Novel procedure for the synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using polymer-supported Burgess reagent under microwave conditions
    Brain, CT
    Paul, JM
    Loong, Y
    Oakley, PJ
    [J]. TETRAHEDRON LETTERS, 1999, 40 (16) : 3275 - 3278
  • [2] IMPROVED FISCHER INDOLE REACTION FOR THE PREPARATION OF N,N-DIMETHYLTRYPTAMINES - SYNTHESIS OF L-695,894, A POTENT 5-HT1D RECEPTOR AGONIST
    CHEN, CY
    SENANAYAKE, CH
    BILL, TJ
    LARSEN, RD
    VERHOEVEN, TR
    REIDER, PJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (13) : 3738 - 3741
  • [3] Parallel synthesis of 1,2,4-oxadiazoles using CDI activation
    Deegan, TL
    Nitz, TJ
    Cebzanov, D
    Pufko, DE
    Porco, JA
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (02) : 209 - 212
  • [4] OXADIAZOLES AS ESTER BIOISOSTERIC REPLACEMENTS IN COMPOUNDS RELATED TO DISOXARIL - ANTIRHINOVIRUS ACTIVITY
    DIANA, GD
    VOLKOTS, DL
    NITZ, TJ
    BAILEY, TR
    LONG, MA
    VESCIO, N
    ALDOUS, S
    PEVEAR, DC
    DUTKO, FJ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (15) : 2421 - 2436
  • [5] HUANG W, 1998, LIZI JIAOHUAN YU XIF, V14, P171
  • [6] QUATERNARY SALT FORMATION OF SUBSTITUTED OXAZOLES AND THIAZOLES
    KERR, VN
    OTT, DG
    HAYES, FN
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (01) : 186 - 189
  • [7] SYNTHESIS OF CARBOXYLIC ACID HYDRAZIDES AND S-TRIAZOLES OF THE ANTHRAQUINONE SERIES
    KLINGSBERG, E
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (21) : 5786 - 5789
  • [8] A new synthesis of 1,3,4-oxadiazoles.: Cyclization of N,N′-diacylhydrazines catalyzed by palladium(0).
    Lutun, S
    Hasiak, B
    Couturier, D
    [J]. SYNTHETIC COMMUNICATIONS, 1999, 29 (01) : 111 - 116
  • [9] Design, synthesis and antiinflammatory activity of some 1,3,4-oxadiazole derivatives
    Omar, FA
    Mahfouz, NM
    Rahman, MA
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (10) : 819 - 825
  • [10] REDDY CK, 1983, SYNTHESIS-STUTTGART, P842
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