Heat-shock proteins and the host-pathogen interaction during bacterial infection

被引：59

作者：

Stewart, GR ^{[1
]}

Young, DB ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Dept Infect Dis & Microbiol, London SW7 2AZ, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.coi.2004.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.

引用

页码：506 / 510

页数：5

共 50 条

[1]

Asea A, 2003, EXERC IMMUNOL REV, V9, P25

[2] Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori [J].