A Monostyryl Boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe for sequential sensing of copper (II) ions and dipicolinic acid as a biomarker of bacterial endospores

被引：53

作者：

Cetinkaya, Yagmur ^{[1
]}

Yurt, Mediha Nur Zafer ^{[2
,3
]}

Oktem, Huseyin Avni ^{[4
,5
]}

Yilmaz, M. Deniz ^{[1
,2
,3
]}

机构：

[1] Konya Food & Agr Univ, Dept Bioengn, Fac Engn & Architecture, TR-42080 Konya, Turkey

[2] Konya Food & Agr Univ, Res & Dev Ctr Diagnost Kits KIT ARGEM, TR-42080 Konya, Turkey

[3] Konya Food & Agr Univ, Inst Sci, Biotechnol Grad Program, TR-42080 Konya, Turkey

[4] Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey

[5] Nanobiz R&D Ltd, Gallium Bld 18,METU Sci Pk, Ankara, Turkey

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2019年 / 377卷

关键词：

Bacterial endospores; Dipicolinic acid; BODIPY; Copper complex; Ratiometric detection; ANTHRAX BIOMARKER; FLUORESCENT DETECTION; BODIPY DERIVATIVES; SPORES; PLATFORM; SENSOR; LIGHT; ASSAY;

D O I：

10.1016/j.jhazmat.2019.05.108

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A new catechol-substituted monostyryl boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe was developed for the sequential detection of Cu2+ ions and dipicolinic acid (DPA), a distinctive biomarker of bacterial endospores, with high sensitivity and selectivity. In the presence of Cu2+ ions, the blue solution of the probe changes to cyan and the fluorescence is quenched, however, the cyan color changes to blue immediately and the fluorescence is restored on contact with DPA, resulting from competitive binding of DPA that interact with Cu2+ ions. A practical application by using Geobacillus stearothermophilus spores was further studied and as low as 1.0 x 10(5) spores were detected.

引用

页码：299 / 304

页数：6

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