Age-Related Hearing Loss

被引:241
作者
Bowl, Michael R. [1 ]
Dawson, Sally J. [2 ]
机构
[1] MRC Harwell Inst, Mammalian Genet Unit, Oxford OX11 0RD, England
[2] UCL, Ear Inst, London WC1X 8EE, England
来源
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2019年 / 9卷 / 08期
关键词
GENOME-WIDE ASSOCIATION; MODERATE ALCOHOL-CONSUMPTION; HAIR-CELL STEREOCILIA; MISSING HERITABILITY; MUTAGENESIS SCREENS; GENE-FUNCTION; MOUSE MODELS; TIP-LINK; COCHLEAR; PREVALENCE;
D O I
10.1101/cshperspect.a033217
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia. Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate age-related auditory decline. However, a prerequisite for design of therapies is knowledge of the underlying molecular mechanisms. Currently, our understanding of ARHL is very limited. Here, we review recent findings from research into ARHL from both human and animal studies and discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL.
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页数:14
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