Protective effect of luteolin on acute lung injury in a rat model of sepsis

被引：14

作者：

Celebi, Demet ^{[1
]}

Aydin, Pelin ^{[2
]}

Cinar, Irfan ^{[3
]}

Kutlu, Zerrin ^{[4
]}

Calik, Ilknur ^{[5
]}

Halici, Zekai ^{[6
]}

Bilici, Dilek ^{[7
]}

Bayraktutan, Zafer ^{[8
]}

机构：

[1] Ataturk Univ, Dept Microbiol, Fac Vet Med, Erzurum, Turkey

[2] Reg Educ & Res Hosp, Dept Anesthesia, Erzurum, Turkey

[3] Kastamonu Univ, Fac Med, Dept Pharmacol, Kastamonu, Turkey

[4] Ataturk Univ, Fac Pharm, Dept Biochem, Erzurum, Turkey

[5] Firat Univ, Fac Med, Dept Pathol, Elazig, Turkey

[6] Ataturk Univ, Fac Med, Dept Pharmacol, Erzurum, Turkey

[7] Reg Educ & Res Hosp, Dept Microbiol, Erzurum, Turkey

[8] Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2021年 / 96卷 / 08期

关键词：

Antioxidants; cecal ligation; IL-10; inflammation; luteolin; rat; sepsis; TNF-alpha; CECAL LIGATION; LIPOPOLYSACCHARIDE; INFLAMMATION; QUERCETIN; TARGET; ASSAY; ACID;

D O I：

10.1080/10520295.2020.1846787

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-alpha and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties.

引用

页码：579 / 585

页数：7

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