Crowding Effects of Membrane Proteins

被引：46

作者：

Zhou, Huan-Xiang ^{[1
,2
]}

机构：

[1] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA

[2] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2009年 / 113卷 / 23期

关键词：

LOCALLY PLANAR SURFACES; LIPID RAFTS; GLOBULAR-PROTEINS; ADSORPTION; AGGREGATION; BINDING; AREA; SIMULATIONS; EQUILIBRIA; OCCUPANCY;

D O I：

10.1021/jp8107446

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In cell membranes, membrane proteins occupy similar to 30% of the total surface area. Crowding effects similar to those in the solution phase are thus to be expected. In addition, there are crowding effects unique to proteins bound to the two-dimensional membranes, such as those exerted on the equilibration of a protein between two membrane orientations and on the redistribution of proteins between different locations in a cell membrane. This article aims to present a theoretical framework for understanding the various crowding effects within membranes. For illustration, the theory is used to analyze previously published experimental and simulation data. It is hoped that the article will encourage quantitative analyses in future experiments and spur systematic investigation of membrane crowding effects.

引用

页码：7995 / 8005

页数：11

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