Gracilioethers A-C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis

被引：61

作者：

Ueoka, Reiko ^{[1
]}

Nakao, Yoichi ^{[1
]}

Kawatsu, Shizuka ^{[1
]}

Yaegashi, Junko ^{[1
]}

Matsumoto, Yoshitsugu ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Furihata, Kazuo ^{[1
]}

van Soest, Rob W. M. ^{[2
]}

Fusetani, Nobuhiro ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Univ Amsterdam, Zool Museum, NL-1090 GT Amsterdam, Netherlands

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 11期

关键词：

NMR; SENSITIVITY; MANZAMINE;

D O I：

10.1021/jo900380f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 mu g/mL, whereas gracilioether B (2) also showed antileishmanial activity.

引用

页码：4203 / 4207

页数：5