Introduction to neutron stimulated emission computed tomography

被引:38
作者
Floyd, Carey E., Jr.
Bender, Janelle E.
Sharma, Amy C.
Kapadia, Anuj
Xia, Jessie
Harrawood, Brian
Tourassi, Georgia D.
Lo, Joseph Y.
Crowell, Alexander
Howell, Calvin
机构
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27710 USA
[2] Duke Univ, Dept Radiol, Duke Adv Imaging Labs, Durham, NC 27710 USA
[3] Duke Univ, Dept Phys, Durham, NC 27710 USA
[4] Duke Univ, Triangle Univ Nucl Lab, Durham, NC 27710 USA
关键词
D O I
10.1088/0031-9155/51/14/006
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Neutron stimulated emission computed tomography (NSECT) is presented as a new technique for in vivo tomographic spectroscopic imaging. A full implementation of NSECT is intended to provide an elemental spectrum of the body or part of the body being interrogated at each voxel of a three-dimensional computed tomographic image. An external neutron beam illuminates the sample and some of these neutrons scatter inelastically, producing characteristic gamma emission from the scattering nuclei. These characteristic gamma rays are acquired by a gamma spectrometer and the emitting nucleus is identified by the emitted gamma energy. The neutron beam is scanned over the body in a geometry that allows for tomographic reconstruction. Tomographic images of each element in the spectrum can be reconstructed to represent the spatial distribution of elements within the sample. Here we offer proof of concept for the NSECT method, present the first single projection spectra acquired from multi-element phantoms, and discuss potential biomedical applications.
引用
收藏
页码:3375 / 3390
页数:16
相关论文
共 56 条
[1]   GEANT4-a simulation toolkit [J].
Agostinelli, S ;
Allison, J ;
Amako, K ;
Apostolakis, J ;
Araujo, H ;
Arce, P ;
Asai, M ;
Axen, D ;
Banerjee, S ;
Barrand, G ;
Behner, F ;
Bellagamba, L ;
Boudreau, J ;
Broglia, L ;
Brunengo, A ;
Burkhardt, H ;
Chauvie, S ;
Chuma, J ;
Chytracek, R ;
Cooperman, G ;
Cosmo, G ;
Degtyarenko, P ;
Dell'Acqua, A ;
Depaola, G ;
Dietrich, D ;
Enami, R ;
Feliciello, A ;
Ferguson, C ;
Fesefeldt, H ;
Folger, G ;
Foppiano, F ;
Forti, A ;
Garelli, S ;
Giani, S ;
Giannitrapani, R ;
Gibin, D ;
Cadenas, JJG ;
González, I ;
Abril, GG ;
Greeniaus, G ;
Greiner, W ;
Grichine, V ;
Grossheim, A ;
Guatelli, S ;
Gumplinger, P ;
Hamatsu, R ;
Hashimoto, K ;
Hasui, H ;
Heikkinen, A ;
Howard, A .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2003, 506 (03) :250-303
[2]   CONCENTRATION OF ELEMENTS IN HUMAN BRAIN - GLIOBLASTOMA-MULTIFORME [J].
ANDRASI, E ;
SUHAJDA, M ;
SARAY, I ;
BEZUR, L ;
ERNYEI, L ;
REFFY, A .
SCIENCE OF THE TOTAL ENVIRONMENT, 1993, 140 :399-402
[3]   Hepatic iron concentration and total body iron stores in thalassemia major. [J].
Angelucci, E ;
Brittenham, GM ;
McLaren, CE ;
Ripalti, M ;
Baronciani, D ;
Giardini, C ;
Galimberti, M ;
Polchi, P ;
Lucarelli, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (05) :327-331
[4]   SELECTIVE DISTRIBUTION OF SELENIUM IN COLON PARALLELS ITS ANTITUMOR-ACTIVITY [J].
BANNER, WP ;
DECOSSE, JJ ;
TAN, QH ;
ZEDECK, MS .
CARCINOGENESIS, 1984, 5 (12) :1543-1546
[5]  
Bataineh ZM, 2002, SAUDI MED J, V23, P218
[6]   Noninvasive measurement of iron: report of an NIDDK workshop [J].
Brittenham, GM ;
Badman, DG .
BLOOD, 2003, 101 (01) :15-19
[7]   Zinc and cadmium analysis in human prostate neoplasms [J].
Brys, M ;
Nawrocka, AD ;
Miekos, E ;
Zydek, C ;
Foksinski, M ;
Barecki, A ;
Krajewska, WM .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1997, 59 (1-3) :145-152
[8]   EFFECT OF KAINATE-INDUCED SEIZURES ON TISSUE TRACE-ELEMENT CONCENTRATIONS IN THE RAT [J].
CARL, GF ;
CRITCHFIELD, JW ;
THOMPSON, JL ;
MCGINNIS, LS ;
WHEELER, GA ;
GALLAGHER, BB ;
HOLMES, GL ;
HURLEY, LS ;
KEEN, CL .
NEUROSCIENCE, 1989, 33 (01) :223-227
[9]  
Chirulescu Z, 1987, Med Interne, V25, P257
[10]  
COHN SH, 1980, ATOM ENERGY REV, V18, P599