A recycling framework for the construction of Bonferroni-based multiple tests

被引:109
作者
Burman, C. -F. [1 ]
Sonesson, C. [1 ]
Guilbaud, O. [2 ]
机构
[1] AstraZeneca R&D, SE-43183 Molndal, Sweden
[2] AstraZeneca R&D, SE-15185 Sodertalje, Sweden
关键词
multiplicity; Bonferroni; Holm; family-wise error rate; gatekeeping; closed tests; CLINICAL-TRIAL APPLICATIONS; GATEKEEPING STRATEGIES;
D O I
10.1002/sim.3513
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this paper we describe Bonferroni-based multiple testing procedures (MTPs) as strategies to split and recycle test mass. Here, 'test mass' refers to (parts of) the nominal level alpha at which the family-wise error rate is controlled. Briefly, test mass is split between different null hypotheses, and whenever a null hypothesis is rejected, the part of alpha allocated to it may be recycled to the testing of other hypotheses. These recycling MTPs are closed testing procedures based on raw p-values associated with testing the individual null hypotheses, and the class of such MTPs includes, for example, serial and parallel gatekeeping, fallback and Holm procedures. Graphical displays and a concise algebraic notation are provided for such MTPs. This recycling approach has pedagogical advantages and may facilitate the tailoring of MTPs for different purposes. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:739 / 761
页数:23
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