The Critical Role of Toll-Like Receptor Signaling Pathways in the Induction and Progression of Autoimmune Diseases

被引：96

作者：

Li, Mingcai ^{[1
]}

Zhou, Yanchun ^{[1
]}

Feng, Guangyou ^{[1
]}

Su, Shao Bo ^{[1
]}

机构：

[1] Shantou Univ, Coll Med, Inst Inflammat & Immune Dis, Shantou 515041, Peoples R China

来源：

CURRENT MOLECULAR MEDICINE | 2009年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Toll-like receptors; ligands; innate immunity; adaptive immunity; autoimmunity; CHRONIC HEPATITIS-C; RHEUMATOID SYNOVIAL FIBROBLASTS; PLASMACYTOID DENDRITIC CELLS; CENTRAL-NERVOUS-SYSTEM; CHRONIC HCV INFECTION; DIET-INDUCED OBESITY; NF-KAPPA-B; INNATE IMMUNITY; MURINE LUPUS; VIRUS-INFECTION;

D O I：

10.2174/156652409787847137

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Toll-like receptors (TLRs) form a large family of pattern recognition receptors with at least 11 members in human and 13 in mouse. TLRs recognize a wide variety of microbial components and potential host-derived agonists that have emerged as key mediators of innate immunity. TLR signaling also plays an important role in the activation of the adaptive immune system by inducing proinflammatory cytokines and upregulating costimulatory molecules of antigen presenting cells. The dysregulation of TLR signaling may cause autoimmunity. This review discusses the contribution of TLR signaling to the initiation and progression of autoimmune diseases, such as rheumatoid arthritis, experimental autoimmune encephalitis, myocarditis, hepatitis, kidney disease, systemic lupus erythematosus, diabetes, obesity, and experimental autoimmune uveitis as well as aging. The involvement of TLR signaling in the pathogenesis of autoimmune diseases may provide novel targets for the development of therapeutics.

引用

页码：365 / 374

页数：10

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