The role of efflux pumps in Bacteroides fragilis resistance to antibiotics

被引：46

作者：

Ghotaslou, Reza ^{[1
,2
]}

Yekani, Mina ^{[2
,3
]}

Memar, Mohammad Yousef ^{[1
,2
,3
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Sch Med, Dept Microbiol, Tabriz, Iran

[3] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

来源：

MICROBIOLOGICAL RESEARCH | 2018年 / 210卷

关键词：

Antibiotic resistance; Bacteroides fragilis; Drug efflux pumps; MULTIDRUG-RESISTANCE; METRONIDAZOLE RESISTANCE; ANTIMICROBIAL RESISTANCE; BIOFILM FORMATION; GENES; SUSCEPTIBILITY; MECHANISMS; BACTERIA; STRAINS; FAMILY;

D O I：

10.1016/j.micres.2018.02.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The resistance of Bacteroides fragilis to the most antimicrobial agents has been reported in the world. Identification of the microbial resistance mechanisms can play an important role in controlling these resistances. Currently, B. fragilis is resistant to most antibiotics. The multi-drug efflux pumps have been shown to underlie the antimicrobial resistance in B. fragilis strains. Two types of these efflux pumps including RND and MATE can be regarded as main structures responsible for antibiotic resistance. Therefore, the strategy for suppressing of this efflux system may be useful in the treatment and control of the multidrug-resistant B. fragilis. The purpose of this study is to review the B. fragilis efflux pumps and their functions in the resistance to antibiotics.

引用

页码：1 / 5

页数：5

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