Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression

被引：75

作者：

Zhang, Qi ^{[1
,2
]}

Lou, Yu ^{[1
,2
]}

Bai, Xue-Li ^{[1
,2
]}

Liang, Ting-Bo ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Hepatobiliary & Pancreat Surg, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Prov Key Lab Pancreat Dis, Hangzhou 310009, Zhejiang, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2018年 / 24卷 / 31期

关键词：

Cholangiocarcinoma; Hepatocellular carcinoma; Tumor microenvironment; Local immune status; Metabolite; FATTY-ACID OXIDATION; INNATE LYMPHOID-CELLS; T-REGULATORY CELLS; HEPATITIS-C VIRUS; FACTOR RECEPTOR 2; HEPATOCELLULAR-CARCINOMA; MACROPHAGE POLARIZATION; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; LIPID-METABOLISM;

D O I：

10.3748/wjg.v24.i31.3500

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The initiation and progression of liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are dependent on its tumor microenvironment. Immune cells are key players in the liver cancer microenvironment and show complicated crosstalk with cancer cells. Emerging evidence has shown that the functions of immune cells are closely related to cell metabolism. However, the effects of metabolic changes of immune cells on liver cancer progression are largely undefined. In this review, we summarize the recent findings of immunometabolism and relate these findings to liver cancer progression. We also explore the translation of the understanding of immunometabolism for clinical use.

引用

页码：3500 / 3512

页数：13

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