Amyotrophic Lateral Sclerosis: A Focus on Disease Progression

被引：29
作者：
Calvo, Ana C. [1 ]
Manzano, Raquel [1 ]
Mendonca, Deise M. F. [2 ]
Munoz, Maria J. [1 ]
Zaragoza, Pilar [1 ]
Osta, Rosario [1 ]
机构：
[1] Univ Zaragoza, Vet Fac Zaragoza, Aragonese Inst Hlth Sci IACS, LAGENBIO I3A, E-50013 Zaragoza, Spain
[2] Univ Fed Sergipe, Dept Biosci, Lab Neurobiol Degenerat Dis Nervous Syst, BR-49500000 Itabaiana, SE, Brazil
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
关键词：
TRANSGENIC MOUSE MODEL; MOTOR-NEURON DISEASE; PROLONGS SURVIVAL; COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; PERIPHERAL-NERVE; TETANUS TOXIN; UP-REGULATION; SPINAL-CORD; STEM-CELLS;
D O I：
10.1155/2014/925101
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases. However, the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives.
引用
收藏
页数：12
相关论文
共 85 条
[1]   Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis [J].
Almer, G ;
Vukosavic, S ;
Romero, N ;
Przedborski, S .
JOURNAL OF NEUROCHEMISTRY, 1999, 72 (06) :2415-2425
[2]  
Azuaje F., 2010, BIOINFORMATICS BIOMA
[3]   VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model [J].
Azzouz, M ;
Ralph, GS ;
Storkebaum, E ;
Walmsley, LE ;
Mitrophanous, KA ;
Kingsman, SM ;
Carmeliet, P ;
Mazarakis, ND .
NATURE, 2004, 429 (6990) :413-417
[4]   Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale [J].
Balendra, Rubika ;
Jones, Ashley ;
Jivraj, Naheed ;
Knights, Catherine ;
Ellis, Catherine M. ;
Burman, Rachel ;
Turner, Martin R. ;
Leigh, P. Nigel ;
Shaw, Christopher E. ;
Al-Chalabi, Ammar .
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 2014, 15 (3-4) :279-284
[5]   Recent advances in amyotrophic lateral sclerosis research: Perspectives for personalized clinical application [J].
Benkler C. ;
Offen D. ;
Melamed E. ;
Kupershmidt L. ;
Amit T. ;
Mandel S. ;
Youdim M.B.H. ;
Weinreb O. .
EPMA Journal, 2010, 1 (2) :343-361
[6]   Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse [J].
Bigini, Paolo ;
Repici, Mariaelena ;
Cantarella, Giuseppina ;
Fumagalli, Elena ;
Barbera, Sara ;
Cagnotto, Alfredo ;
De Luigi, Ada ;
Tonelli, Rossella ;
Bernardini, Renato ;
Borsello, Tiziana ;
Mennini, Tiziana .
NEUROBIOLOGY OF DISEASE, 2008, 29 (03) :465-476
[7]   OXIDATIVE STRESS-INDUCED BY GLUTAMATE RECEPTOR AGONISTS [J].
BONDY, SC ;
LEE, DK .
BRAIN RESEARCH, 1993, 610 (02) :229-233
[8]   APPLYING PROTEOMICS TO THE DIAGNOSIS AND TREATMENT OF ALS AND RELATED DISEASES [J].
Bowser, Robert ;
Lacomis, David .
MUSCLE & NERVE, 2009, 40 (05) :753-762
[9]   Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker [J].
Boylan, Kevin ;
Yang, Cui ;
Crook, Julia ;
Overstreet, Karen ;
Heckman, Michael ;
Wang, Yong ;
Borchelt, David ;
Shaw, Gerry .
JOURNAL OF NEUROCHEMISTRY, 2009, 111 (05) :1182-1191
[10]   El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis [J].
Brooks, BR ;
Miller, RG ;
Swash, M ;
Munsat, TL .
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2000, 1 (05) :293-299
123456789