Supercritical antisolvent coprecipitation mechanisms

被引：65

作者：

Prosapio, Valentina ^{[1
]}

De Marco, Iolanda ^{[1
]}

Reverchon, Ernesto ^{[1
]}

机构：

[1] Univ Salerno, Dept Ind Engn, Via Giovanni Paolo II 132, I-84084 Fisciano Sa, Italy

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2018年 / 138卷

关键词：

Supercritical antisolvent; Coprecipitation; Precipitation mechanisms; Microparticles; Nanoparticles; ANTIINFLAMMATORY DRUG DIFLUNISAL; SOLUTION-ENHANCED DISPERSION; ANTI-SOLVENT PRECIPITATION; CARBON-DIOXIDE; COMPOSITE MICROPARTICLES; POLYMER MICROPARTICLES; IN-VITRO; NANOPARTICLES PRECIPITATION; POLY(L-LACTIC ACID); CONTROLLED DELIVERY;

D O I：

10.1016/j.supflu.2018.04.021

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Supercritical antisolvent precipitation (SAS) has been successfully used to produce microparticles and nano-particles of controlled size and distribution either as a single precipitates or by coprecipitation of two or more compounds. SAS coprecipitation process has produced different particles morphologies and, differently from the single compound SAS precipitation, process mechanisms involved have never been elucidated and the effectiveness of the technique has been verified only in some cases. In this work, the mechanisms proposed in SAS coprecipitation are critically discussed and general indications about coprecipitation efficiency are given, based on several experimental evidences and on the possible underlying nucleation, growth and drying mechanisms. The most effective and reliable SAS coprecipitation resulted from the formation of microdroplets and their subsequent drying.

引用

页码：247 / 258

页数：12

共 135 条

[1] Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process [J].

Alias, Dalila ;

Yunus, Robiah ;

Chong, Gun Hean ;

Abdullah, Che Azurahanim Che .

POWDER TECHNOLOGY, 2017, 309 :89-94

[2] Characterization of azacytidine/poly(L-lactic) acid particles prepared by supercritical antisolvent precipitation [J].

Argemi, Anna ;

Vega, Arlette ;

Subra-Paternault, Pascale ;

Saurina, Javier .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 50 (05) :847-852

[3] Increasing the dissolution rate of itraconazole processed by gas antisolvent techniques using polyethylene glycol as a carrier [J].

Barrett, Angela Mary ;

Dehghani, Fariba ;

Foster, Neil R. .

PHARMACEUTICAL RESEARCH, 2008, 25 (06) :1274-1289

[4] Encapsulation of bixin in PHBV using SEDS technique and in vitro release evaluation [J].

Boschetto, Daiane L. ;

Aranha, Estela M. ;

Ulson de Souza, Antonio A. ;

Souza, Selene M. A. Guelli U. ;

Ferreira, Sandra R. S. ;

Priamo, Wagner L. ;

Oliveira, J. Vladimir .

INDUSTRIAL CROPS AND PRODUCTS, 2014, 60 :22-29

[5] Phase behavior and process parameters effect on grape seed extract encapsulation by SEDS technique [J].

Boschetto, Daiane L. ;

Dalmolin, Irede ;

de Cesaro, Alana M. ;

Rigo, Aline A. ;

Ferreira, Sandra R. S. ;

Meireles, M. Angela A. ;

Batista, Eduardo A. C. ;

Vladimir Oliveira, J. .

INDUSTRIAL CROPS AND PRODUCTS, 2013, 50 :352-360

[6] Development of Aerosol Phospholipid Microparticles for the Treatment of Pulmonary Hypertension [J].

Brousseau, Sarah ;

Wang, Zimeng ;

Gupta, Sweta K. ;

Meenach, Samantha A. .

AAPS PHARMSCITECH, 2017, 18 (08) :3247-3257

[7] Generation of fine powders of recombinant human deoxyribonuclease using the aerosol solvent extraction system [J].

Bustami, RT ;

Chan, HK ;

Sweeney, T ;

Dehghani, F ;

Foster, NR .

PHARMACEUTICAL RESEARCH, 2003, 20 (12) :2028-2035

[8] Dependence of SAS particle morphologies on the ternary phase equilibria [J].

Campardelli, R. ;

Reverchon, E. ;

De Marco, I. .

JOURNAL OF SUPERCRITICAL FLUIDS, 2017, 130 :273-281

[9] Application of Poly(styrene-co-divinylbenzene) Macroporous Microparticles as a Catalyst Support in the Enzymatic Synthesis of Biodiesel [J].

Castiglioni, Gabriel L. ;

Cuellar, Jorge ;

Rodrigo, Raul ;

Costa, Jorge A. V. ;

Monte-Alegre, Ranulfo .

JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2016, 24 (03) :264-273

[10] Role of phase behavior in micronization of lysozyme via a supercritical anti-solvent process [J].

Chang, Shan-Chun ;

Lee, Min-Jer ;

Lin, Ho-Mu .

CHEMICAL ENGINEERING JOURNAL, 2008, 139 (02) :416-425

← 1 2 3 4 5 6 7 8 9 10 →