Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation

被引：1
|
作者：
Ko, Eunah [1 ]
Kim, Kanghwan [1 ,2 ]
Voroslakos, Mihaly [1 ,3 ]
Oh, Sungjin [1 ]
Buzsaki, Gyorgy [3 ]
Wise, Kensall D. [1 ]
Yoon, Euisk [1 ,4 ,5 ,6 ]
机构：
[1] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA
[2] Korea Inst Sci & Technol, Brain Sci Inst, Ctr BioMicrosyst, Seoul 02792, South Korea
[3] New York Univ, Neurosci Inst, Langone Med Ctr, New York, NY 10016 USA
[4] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[5] Yonsei Univ, Inst Basic Sci IBS, Ctr Nanomed, Seoul 03722, South Korea
[6] Yonsei Univ, Adv Sci Inst, Grad Program Nano Biomed Engn Nano BME, Seoul 03722, South Korea
来源：
2022 INTERNATIONAL ELECTRON DEVICES MEETING, IEDM | 2022年
关键词：
D O I：
10.1109/IEDM45625.2022.10019379
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Evolution of "Michigan Probes" has enabled unraveling the connectivity of neurons at cellular resolution and their dynamic interaction within and across brain areas that underlie behavioral and cognitive functions. Recently, micro-LEDs were monolithically integrated for optogenetic neuromodulation at scale without requiring external optical fiber connection. The 'hectoSTAR' micro-LED optoelectrode features 256 recording electrodes and 128 stimulation micro-LEDs in four silicon micro-needle shanks, covering a large volume with 1.3-mm x 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. Technical challenges to overcome in scaling of optogenetic probes will be discussed, followed by future direction.
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页数：4
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