Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

被引：121
作者：
Mahmoud, Yasmina K. [1 ]
Abdelrazek, Heba [2 ]
机构：
[1] Suez Canal Univ, Fac Vet Med, Biochem Dept, Ismailia 41522, Egypt
[2] Suez Canal Univ, Fac Vet Med, Physiol Dept, Ismailia 41522, Egypt
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 115卷
关键词：
Angiogenesis; Anticancer; Apoptosis; Pro-oxidant; Thymoquinone; NIGELLA-SATIVA OIL; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; HEME OXYGENASE-1 EXPRESSION; RENAL-CELL CARCINOMA; OXIDATIVE STRESS; INHIBITS PROLIFERATION; GASTRIC-CANCER; MAP KINASE; IN-VITRO; MOLECULAR-MECHANISMS;
D O I：
10.1016/j.biopha.2019.108783
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recently, there is growing interest in the natural bioactive components having anticancer activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa), has promising properties including anticancer and chemosensitizing peculiarities. The anticancer power of TQ is accomplished by several aspects; including promotion of apoptosis, arrest of cell cycle and ROS generation. In addition, it boosts the immune system and lessens the side effects associated with traditional anticancer therapy. TQ also controls angiogenesis and cancer metastasis. This review focuses on the potential aspects and mechanisms by which TQ acquires its actions.
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页数：14
相关论文
共 181 条
[1]   Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats [J].
Abdelrazek, Heba M. A. ;
Kilany, Omnia E. ;
Muhammad, Muhammad A. A. ;
Tag, Hend M. ;
Abdelazim, Aaser M. .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[2]   Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats [J].
Ahmad, Shafeeque ;
Beg, Zafarul H. .
FOOD CHEMISTRY, 2013, 138 (2-3) :1116-1124
[3]  
Al-Amri A. M., 2009, Shiraz E Medical Journal, V10, P107
[4]  
Al-Shabanah OA, 1998, J EXP CLIN CANC RES, V17, P193
[5]   Cytotoxicity of thymoquinone alone or in combination with cisplatin (CDDP) against oral squamous cell carcinoma in vitro [J].
Alaufi, Omar M. ;
Noorwali, Abdulwahab ;
Zahran, Fatheya ;
Al-Abd, Ahmed M. ;
Al-Attas, Safia .
SCIENTIFIC REPORTS, 2017, 7
[6]   Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide [J].
Alenzi, F. Q. ;
El-Bolkiny, Y. El-Sayer ;
Salem, M. L. .
BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 2010, 67 (01) :20-28
[7]   Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1 [J].
Alhosin, Mahmoud ;
Abusnina, Abdurazzag ;
Achour, Mayada ;
Sharif, Tanveer ;
Muller, Christian ;
Peluso, Jean ;
Chataigneau, Thierry ;
Lugnier, Claire ;
Schini-Kerth, Valerie B. ;
Bronner, Christian ;
Fuhrmann, Guy .
BIOCHEMICAL PHARMACOLOGY, 2010, 79 (09) :1251-1260
[8]   CHEMICAL-COMPOSITION AND MICROFLORA OF BLACK CUMIN (NIGELLA-SATIVA L) SEEDS GROWING IN SAUDI-ARABIA [J].
ALJASSIR, MS .
FOOD CHEMISTRY, 1992, 45 (04) :239-242
[9]   Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer [J].
Alobaedi, Omar H. ;
Talib, Wamidh H. ;
Basheti, Iman A. .
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2017, 10 (04) :378-386
[10]  
[Anonymous], 2014, ENCY BRITANNICA
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