Melanoma Adjuvant Therapy

被引：10

作者：

Tarhini, Ahmad A. ^{[1
]}

Thalanayar, Prashanth M. ^{[2
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Dept Med, Pittsburgh, PA 15232 USA

[2] Univ Pittsburgh, Dept Internal Med, Med Ctr, Pittsburgh, PA 15213 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 03期

关键词：

Adjuvant; Melanoma; Interferon; Ipilimumab; HIGH-RISK MELANOMA; PHASE-III TRIAL; HIGH-DOSE INTERFERON-ALPHA-2B; REGIONAL NODAL METASTASES; RADIATION-THERAPY; MALIGNANT-MELANOMA; PROGNOSTIC-SIGNIFICANCE; CUTANEOUS MELANOMA; COMPLETE RESECTION; RANDOMIZED-TRIAL;

D O I：

10.1016/j.hoc.2014.02.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adjuvant therapy targets melanoma micrometastases in patients with surgically resected disease that carry a high risk of death from melanoma recurrence. In this setting, adjuvant therapy provides the greatest opportunity for cure before progression into advanced inoperable stages. In randomized clinical trials, interferon-alfa has been shown to have a significant impact on relapse-free survival and, at high dosage, on overall survival compared with observation (E1684) and the GMK vaccine (E1694). This article reviews melanoma adjuvant therapy along with the ongoing and planned clinical trials.

引用

页码：471 / +

页数：21

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