High-speed electroseparations inside silica colloidal crystals

被引:57
作者
Zheng, Suping [1 ]
Ross, Eric [1 ]
Legg, Michael A. [1 ]
Wirth, Mary J. [1 ]
机构
[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA
关键词
D O I
10.1021/ja062676l
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Crystals made from 200 nm silica colloids are hardened and chemically modified with chlorodimethyloctadecylsilane for use in electrically driven, reversed-phase separations. A van Deemter plot reveals extremely narrow peak widths for the separation of a cationic hydrophobic dye, DiI, with both the A and C terms 10-fold smaller than those for a conventional HPLC column. Electrically driven separations are demonstrated to be achieved in less than 10 s for three dyes differing in hydrophobicity and also for three peptides differing in electrophoretic mobility. The results show that these media are promising for high-speed separations. Copyright © 2006 American Chemical Society.
引用
收藏
页码:9016 / 9017
页数:2
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