Low ethanol concentrations selectively augment the tonic inhibition mediated by δ subunit-containing GABAA receptors in hippocampal neurons

被引：193

作者：

Wei, WZ

Faria, LC

Mody, I

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, BR-04023900 Sao Paulo, Brazil

来源：

JOURNAL OF NEUROSCIENCE | 2004年 / 24卷 / 38期

关键词：

alcohol; CA1; dentate; GABA; hippocampus; inhibition;

D O I：

10.1523/JNEUROSCI.2040-04.2004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of CA1 pyramidal cells is not affected. The effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the delta subunit-dependent tonic inhibition as a likely site of ethanol action in the brain.

引用

页码：8379 / 8382

页数：4

共 18 条

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) : 14439 - 14444
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (10) : 3104 - 3109
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[9] Induction of Inhibitory Synaptic Plasticity Enhances Tonic Current by Increasing the Content of α5-Subunit Containing GABAA Receptors in Hippocampal Pyramidal Neurons
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