Synthesis of carbon dots from Hypocrella bambusae for bimodel fluorescence/photoacoustic imaging-guided synergistic photodynamic/photothermal therapy of cancer

被引：120

作者：

Ji, Qingyan ^{[1
,2
,3
]}

Zheng, Xiuli ^{[1
,2
,3
]}

Ge, Jiechao ^{[1
,2
,3
]}

Liu, Weimin ^{[1
,2
,3
]}

Ren, Haohui ^{[1
,2
]}

Chen, Shiqing ^{[1
,2
,3
]}

Wen, Yongmei ^{[1
,2
,3
]}

Zhang, Hongyan ^{[1
,2
]}

Wu, Jiasheng ^{[1
,2
]}

Wang, Pengfei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Tech Inst Phys & Chem, CityU CAS Joint Lab Funct Mat & Devices, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2018年 / 526卷

基金：

中国国家自然科学基金;

关键词：

Carbon dot; Photodynamic therapy; Photothermal therapy; PHOTODYNAMIC THERAPY; QUANTUM DOTS; THERMAL THERANOSTICS; PHOTOTHERMAL THERAPY; MESOPOROUS CARBON; NANOPARTICLES; FLUORESCENT; AGENTS; RED; PHOTOSENSITIZER;

D O I：

10.1016/j.jcis.2018.05.005

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

As phototheranostic agents, carbon dots (CDs), have recently drawn considerable attention due to their excellent physicochemical properties. However, the complex synthetic route and high-cost of CDs greatly limit their practical application. To address this issue, given their nearly infinite supply from nature, Hypocrella bambusae is used as the precursor for the preparation of CDs in this study. The obtained Hypocrella bambusae CDs (HBCDs) possess good water solubility, broad absorption (350-800 nm), red-light emission (maximum peak at 610 nm), and low biotoxicity. Moreover, HBCDs can highly generate O-1(2) (0.38) and heat (27.6%) under 635 nm laser irradiation. These excellent properties of HBCDs capacitate them to be utilized for bimodal fluorescence/photoacoustic imaging-guided synergistic photodynamic therapy (PDT)/photothermal therapy (PTT). This work provides a new candidate for tumor treatment with the combination of PDT and PIT, and explores a novel approach for the preparation of CD-based phototheranostic agents with natural biomass as raw carbon sources. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：302 / 311

页数：10

共 79 条

[41] Antimicrobial and antileishmanial activities of hypocrellins A and B [J].