Nonlinear elasticity of stiff biopolymers connected by flexible linkers

被引：72

作者：

Kasza, K. E. ^{[1
]}

Koenderink, G. H. ^{[1
]}

Lin, Y. C. ^{[1
]}

Broedersz, C. P. ^{[3
]}

Messner, W. ^{[2
]}

Nakamura, F. ^{[2
]}

Stossel, T. P. ^{[2
]}

MacKintosh, F. C. ^{[3
]}

Weitz, D. A. ^{[1
]}

机构：

[1] Harvard Univ, Dept Phys & SEAS, Cambridge, MA 02138 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Translat Med Div, Boston, MA 02115 USA

[3] Vrije Univ Amsterdam, Dept Phys & Astron, NL-1081 HV Amsterdam, Netherlands

来源：

PHYSICAL REVIEW E | 2009年 / 79卷 / 04期

基金：

美国国家科学基金会;

关键词：

biorheology; elasticity; molecular biophysics; proteins; shear deformation; POLYMER NETWORKS; ACTIN-FILAMENTS; ALPHA-ACTININ; MECHANICS; PROTEINS; FILAMINS; STRESS; FORCE;

D O I：

10.1103/PhysRevE.79.041928

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Networks of the biopolymer actin, cross-linked by the compliant protein filamin, form soft gels. They can, however, withstand large shear stresses due to their pronounced nonlinear elastic behavior. The nonlinear elasticity can be controlled by varying the number of cross-links per actin filament. We propose and test a model of rigid filaments decorated by multiple flexible linkers that is in quantitative agreement with experiment. This allows us to estimate loads on individual cross-links, which we find to be less than 10 pN.

引用

页数：5

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