Nanoengineered Particles for Enhanced Intra-Articular Retention and Delivery of Proteins

被引：63
作者：
Singh, Ankur [1 ,2 ]
Agarwal, Rachit [1 ]
Diaz-Ruiz, Carlos A. [1 ]
Willett, Nick J. [1 ]
Wang, Peiyi [3 ]
Lee, L. Andrew [3 ,4 ]
Wang, Qian [3 ]
Guldberg, Robert E. [1 ,5 ]
Garcia, Andres J. [1 ,5 ]
机构：
[1] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA
[2] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA
[3] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29205 USA
[4] A&Q NanoDesigns LLC, Columbia, SC 29201 USA
[5] Georgia Inst Technol, Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
来源：
ADVANCED HEALTHCARE MATERIALS | 2014年 / 3卷 / 10期
基金：
美国国家科学基金会;
关键词：
nanoparticles; osteoarthritis; protein delivery; biomaterials; COLLAGEN-INDUCED ARTHRITIS; SYNOVIAL MACROPHAGES; II COLLAGEN; OSTEOARTHRITIS; NANOPARTICLES; MICROSPHERES; POLYMER; BIONANOPARTICLES; FIBRONECTIN; INTERFACES;
D O I：
10.1002/adhm.201400051
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1562 / 1567
页数：6
相关论文
共 34 条
[1]   Effects of interleukin-1 receptor antagonist in a slow-release hylan vehicle on rat type II collagen arthritis [J].
Bendele, A ;
McAbee, T ;
Woodward, M ;
Scherrer, J ;
Collins, D ;
Frazier, J ;
Chlipala, E ;
McCabe, D .
PHARMACEUTICAL RESEARCH, 1998, 15 (10) :1557-1561
[2]   The Role of Synovial Macrophages and Macrophage-Produced Mediators in Driving Inflammatory and Destructive Responses in Osteoarthritis [J].
Bondeson, Jan ;
Blom, Arjen B. ;
Wainwright, Shane ;
Hughes, Clare ;
Caterson, Bruce ;
van den Berg, Wim B. .
ARTHRITIS AND RHEUMATISM, 2010, 62 (03) :647-657
[3]   Activated Synovial Macrophages as Targets for Osteoarthritis Drug Therapy [J].
Bondeson, Jan .
CURRENT DRUG TARGETS, 2010, 11 (05) :576-585
[4]   Osteoarthritis, angiogenesis and inflammation [J].
Bonnet, CS ;
Walsh, DA .
RHEUMATOLOGY, 2005, 44 (01) :7-16
[5]   Evaluation of Eudragit® RS-PO and Ethocel® 100 matrices for the controlled release of lobenzarit disodium [J].
Boza, A ;
Caraballo, I ;
Alvarez-Fuentes, J ;
Rabasco, AM .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1999, 25 (02) :229-233
[6]   Etiopathogenesis of Osteoarthritis [J].
Brandt, Kenneth D. ;
Dieppe, Paul ;
Radin, Eric .
MEDICAL CLINICS OF NORTH AMERICA, 2009, 93 (01) :1-+
[7]   Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis [J].
Butoescu, Nicoleta ;
Seemayer, Christian A. ;
Foti, Michelangelo ;
Jordan, Olivier ;
Doelker, Eric .
BIOMATERIALS, 2009, 30 (09) :1772-1780
[8]   Estimates of the prevalence of arthritis and other rheumatic conditions in the United States [J].
Helmick, Charles G. ;
Felson, David T. ;
Lawrence, Reva C. ;
Gabriel, Sherine ;
Hirsch, Rosemarie ;
Kwoh, C. Kent ;
Liang, Matthew H. ;
Kremers, Hilal Maradit ;
Mayes, Maureen D. ;
Merkel, Peter A. ;
Pillemer, Stanley R. ;
Reveille, John D. ;
Stone, John H. .
ARTHRITIS AND RHEUMATISM, 2008, 58 (01) :15-25
[9]   Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium [J].
Horisawa, E ;
Kubota, K ;
Tuboi, I ;
Sato, K ;
Yamamoto, H ;
Takeuchi, H ;
Kawashima, Y .
PHARMACEUTICAL RESEARCH, 2002, 19 (02) :132-139
[10]   Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit [J].
Horisawa, E ;
Hirota, T ;
Kawazoe, S ;
Yamada, J ;
Yamamoto, H ;
Takeuchi, H ;
Kawashima, Y .
PHARMACEUTICAL RESEARCH, 2002, 19 (04) :403-410
1234