Toxic Effects of Bisphenol A on Early Life Stages of Japanese Medaka (Oryzias latipes)

被引：21

作者：

Sun, Liwei ^{[1
]}

Lin, Xia ^{[1
]}

Jin, Rong ^{[1
]}

Peng, Tao ^{[1
]}

Peng, Zuhua ^{[1
]}

Fu, Zhengwei ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Biol & Environm Engn, Hangzhou 310032, Zhejiang, Peoples R China

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2014年 / 93卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Endocrine disruption; Steroid synthesis; Vitellogenin; Gender-specificity; VITELLOGENIN INDUCTION; EXPRESSION; CHEMICALS; FISH; GENES; PCR; MARMORATUS; EXPOSURE; RECEPTOR;

D O I：

10.1007/s00128-014-1298-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The toxic effects of bisphenol A (BPA) in aquatic organisms have attracted global attention. However, few studies have investigated its effects at the gene transcription level. In this study, we measured the transcriptional response of a set of genes associated with the hypothalamic-pituitary-gonadal axis following BPA exposure during the early life stage of Japanese medaka. Transcription of vitellogenin genes was induced in both sexes, indicating estrogenic disruption. However, changes in transcription of the steroid hormone receptor gene and steroidogenesis-regulating genes suggest that BPA also acts as an androgen receptor antagonist. BPA exposure also decreased the hatchability of medaka embryos and increased the growth of female larvae. These pronounced gender-specific effects observed in this study demonstrate that it is important to identify the sex of fish in the early life stage.

引用

页码：222 / 227

页数：6

共 26 条

[1] Effect of alkylphenols on adult male medaka: plasma vitellogenin goes up to the level of estrous female [J].

Chikae, M ;

Ikeda, R ;

Hasan, Q ;

Morita, Y ;

Tamiya, E .

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2003, 15 (01) :33-36

[2] An ecological assessment of bisphenol-A: Evidence from comparative biology [J].

Crain, D. Andrew ;

Eriksen, Marcus ;

Iguchi, Taisen ;

Jobling, Susan ;

Laufer, Hans ;

LeBlanc, Gerald A. ;

Guillette, Louis J., Jr. .

REPRODUCTIVE TOXICOLOGY, 2007, 24 (02) :225-239

[3] Bisphenol A Exposure: Human Risk and Health Policy [J].

Erler, Cheryl ;

Novak, Julie .

JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES, 2010, 25 (05) :400-407

[4]

European Commission, 2010, EUR UN RISK ASS REP

[5] Gene expression profiles revealing the mechanisms of anti-androgen-and estrogen-induced feminization in fish [J].

Filby, Amy L. ;

Thorpe, Karen L. ;

Maack, Gerd ;

Tyler, Charles R. .

AQUATIC TOXICOLOGY, 2007, 81 (02) :219-231

[6] Bisphenol A exposure, effects, and policy: A wildlife perspective [J].

Flint, Shelby ;

Markle, Tricia ;

Thompson, Sarah ;

Wallace, Elizabeth .

JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2012, 104 :19-34

[7]

Hayashi Hitomi, 2007, Journal of Toxicological Sciences, V32, P91, DOI 10.2131/jts.32.91

[8] Toxicity to early life stages and an estrogenic effect of a bisphenol A metabolite, 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene on the medaka (Oryzias latipes) [J].

Ishibashi, H ;

Watanabe, N ;

Matsumura, N ;

Hirano, M ;

Nagao, Y ;

Shiratsuchi, H ;

Kohra, S ;

Yoshihara, S ;

Arizono, K .

LIFE SCIENCES, 2005, 77 (21) :2643-2655

[9]

Japanese Ministry of the Environment, 2006, RES ASS TESTS EV END

[10] Effects of bisphenol A on the reproduction of Japanese medaka (Oryzias latipes) [J].

Kang, IJ ;

Yokota, H ;

Oshima, Y ;

Tsuruda, Y ;

Oe, T ;

Imada, N ;

Tadokoro, H ;

Honjo, T .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2002, 21 (11) :2394-2400

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