Dupilumab: An emerging therapy in allergic fungal rhinosinusitis

被引：20

作者：

Bulkhi, Adeeb A. ^{[1
,2
,3
]}

Mirza, Ahmad A. ^{[4
,5
]}

Aburiziza, Abdullah J. ^{[6
]}

Marglani, Osama A. ^{[7
,8
]}

机构：

[1] Umm Al Qura Univ, Coll Med, Dept Internal Med, Mecca, Saudi Arabia

[2] Univ S Florida, Morsani Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL 33620 USA

[3] King Abdullah Med City, Dept Allergy & Immunol, Mecca, Saudi Arabia

[4] King Abdulaziz Univ, Fac Med Rabigh, Dept Otolaryngol Head & Neck Surg, POB 80200, Jeddah 21589, Saudi Arabia

[5] Univ Toronto, Temerty Fac Med, Dept Otolaryngol Head & Neck Surg, Toronto, ON, Canada

[6] Umm Al Qura Univ UQU, Dept Pediat, Mecca, Saudi Arabia

[7] Umm Al Qura Univ, Fac Med, Dept Ophthalmol, Mecca, Saudi Arabia

[8] King Faisal Specialist Hosp & Res Ctr, Dept Surg, Jeddah, Saudi Arabia

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2022年 / 15卷 / 03期

关键词：

Biological therapies; Hypersensitivity; Nasal polyp; Sinusitis; Saudi Arabia; PREVALENCE; DIAGNOSIS; MODERATE; IGE;

D O I：

10.1016/j.waojou.2022.100638

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergic fungal rhinosinusitis (AFRS) is a highly resistant disease and is challenging to treat. Patients with recurrent attacks of the disease despite surgical management can benefit from biologics as adjunct therapies. Dupilumab has shown promising endpoints in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). This case series reports 4 patients with resistant AFRS concomitant with asthma, for which dupilumab therapy was administered. Long-term follow-ups showed that dupilumab improved the symptoms and improved the results of objective tools such as and function test.

引用

页数：9

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