Potential role of gastrointestinal microbiota composition in prostate cancer risk

被引:38
作者
Amirian, E. Susan [1 ,2 ]
Petrosino, Joseph F. [3 ,4 ]
Ajami, Nadim J. [3 ,4 ]
Liu, Yanhong [1 ,2 ]
Mims, Martha P. [5 ]
Scheurer, Michael E. [1 ,2 ]
机构
[1] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Molcular Virol & Microbiol, Houston, TX 77030 USA
[4] Baylor Coll Med, Alkek Ctr Metagen & Microbiome Res, Houston, TX 77030 USA
[5] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
关键词
Human microbiome; Metagenome; Prostate cancer; Metabolic process; FOOD-BORNE CARCINOGEN; GUT MICROBIOTA; DAIRY-PRODUCTS; LACTOBACILLUS-ACIDOPHILUS; COLORECTAL-CANCER; MEAT INTAKE; LIFE-STYLE; RED MEAT; METABOLISM; CALCIUM;
D O I
10.1186/1750-9378-8-42
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Among men in the U. S., prostate cancer is the most common cancer and the second leading cause of cancer death. Despite its prevalence, there are few established risk factors for prostate cancer. Some studies have found that intake of certain foods/nutrients may be associated with prostate cancer risk, but few have accounted for how intake and metabolic factors may interact to influence bioavailable nutrient levels and subsequent disease risk. Presentation of the hypothesis: The composition of the gastrointestinal (GI) microbiome may influence metabolism of dietary compounds and nutrients (e. g., plant phenols, calcium, choline) that may be relevant to prostate cancer risk. We, therefore, propose the hypothesis that GI microbiota may have a markedly different composition among individuals with higher prostate cancer risk. These individuals could have microbial profiles that are conducive to intestinal inflammation and/or are less favorable for the metabolism and uptake of chemopreventive agents. Testing the hypothesis: Because very little preliminary data exist on this potential association, a case-control study may provide valuable information on this topic. Such a study could evaluate whether the GI microbial profile is markedly different between three groups of individuals: healthy men, those with latent prostate cancer, and those with invasive prostate cancer. Any findings could then be validated in a larger study, designed to collect a series of specimens over time. Implications of the hypothesis: Given the plethora of information emerging from the Human Microbiome Project, this is an opportune time to explore associations between the microbiome and complex human diseases. Identification of profiles that alter the host's risk for disease may clarify inconsistencies in the literature on dietary factors and cancer risk, and could provide valuable targets for novel cancer prevention strategies.
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页数:7
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共 76 条
[1]   Prostate cancer chemoprevention by soy isoflavones: Role of intestinal bacteria as the "second human genome" [J].
Akaza, Hideyuki .
CANCER SCIENCE, 2012, 103 (06) :969-975
[2]   A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer [J].
Alexander, Dominik D. ;
Mink, Pamela J. ;
Cushing, Colleen A. ;
Sceurman, Bonnie .
NUTRITION JOURNAL, 2010, 9
[3]   Associations Between Arachidonic Acid Metabolism Gene Polymorphisms and Prostate Cancer Risk [J].
Amirian, E. Susan ;
Ittmann, Michael M. ;
Scheurer, Michael E. .
PROSTATE, 2011, 71 (13) :1382-1389
[4]   Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation [J].
Antonopoulos, Dionysios A. ;
Huse, Susan M. ;
Morrison, Hilary G. ;
Schmidt, Thomas M. ;
Sogin, Mitchell L. ;
Young, Vincent B. .
INFECTION AND IMMUNITY, 2009, 77 (06) :2367-2375
[5]   Fecal microbiota transplantation: past, present and future [J].
Aroniadis, Olga C. ;
Brandt, Lawrence J. .
CURRENT OPINION IN GASTROENTEROLOGY, 2013, 29 (01) :79-84
[6]   Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota [J].
Arthur, Janelle C. ;
Perez-Chanona, Ernesto ;
Muehlbauer, Marcus ;
Tomkovich, Sarah ;
Uronis, Joshua M. ;
Fan, Ting-Jia ;
Campbell, Barry J. ;
Abujamel, Turki ;
Dogan, Belgin ;
Rogers, Arlin B. ;
Rhodes, Jonathan M. ;
Stintzi, Alain ;
Simpson, Kenneth W. ;
Hansen, Jonathan J. ;
Keku, Temitope O. ;
Fodor, Anthony A. ;
Jobin, Christian .
SCIENCE, 2012, 338 (6103) :120-123
[7]   Dietary n-6 and n-3 polyunsaturated fatty acids and prostate cancer risk:: a review of epidemiological and experimental evidence [J].
Astorg, P .
CANCER CAUSES & CONTROL, 2004, 15 (04) :367-386
[8]   The gut microbiota as an environmental factor that regulates fat storage [J].
Bäckhed, F ;
Ding, H ;
Wang, T ;
Hooper, LV ;
Koh, GY ;
Nagy, A ;
Semenkovich, CF ;
Gordon, JI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723
[9]   History of allergies and autoimmune diseases and risk of brain tumors in adults [J].
Brenner, AV ;
Linet, MS ;
Fine, HA ;
Shapiro, WR ;
Selker, RG ;
Black, PM ;
Inskip, PD .
INTERNATIONAL JOURNAL OF CANCER, 2002, 99 (02) :252-259
[10]   Estrogen and prostate cancer: An eclipsed truth in an androgen-dominated scenario [J].
Carruba, Giuseppe .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 102 (04) :899-911