Microbiota-Dependent Effects of IL-22

被引:29
作者
Sabihi, Morsal [1 ]
Boettcher, Marius [1 ]
Pelczar, Penelope [1 ]
Huber, Samuel [1 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Martinistr 52, D-20246 Hamburg, Germany
关键词
IL-22; IL-22BP; microbiota; cytokines; inflammation; INNATE LYMPHOID-CELLS; HEPATITIS-C VIRUS; T-CELL; INTERLEUKIN; 22; BINDING-PROTEIN; GUT MICROBIOTA; TH17; CELLS; INDUCIBLE FACTOR; PROTECTIVE ROLE; HOST-DEFENSE;
D O I
10.3390/cells9102205
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cytokines are important contributors to immune responses against microbial and environmental threats and are of particular importance at epithelial barriers. These interfaces are continuously exposed to external factors and thus require immune components to both protect the host from pathogen invasion and to regulate overt inflammation. Recently, substantial efforts have been devoted to understanding how cytokines act on certain cells at barrier sites, and why the dysregulation of immune responses may lead to pathogenesis. In particular, the cytokine IL-22 is involved in preserving an intact epithelium, maintaining a balanced microbiota and a functioning defense system against external threats. However, a tight regulation of IL-22 is generally needed, since uncontrolled IL-22 production can lead to the progression of autoimmunity and cancer. Our aim in this review is to summarize novel findings on IL-22 and its interactions with specific microbial stimuli, and subsequently, to understand their contributions to the function of IL-22 and the clinical outcome. We particularly focus on understanding the detrimental effects of dysregulated control of IL-22 in certain disease contexts.
引用
收藏
页码:1 / 19
页数:19
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