Septic shock: The initial moments and beyond

被引:7
作者
Lam, Simon W. [1 ]
Bauer, Seth R. [1 ]
Guzman, Jorge A. [2 ]
机构
[1] Cleveland Clin, Dept Pharm, Cleveland, OH 44195 USA
[2] Cleveland Clin, Med Intens Care Unit, Sect Crit Care Med, Cleveland, OH 44195 USA
关键词
GOAL-DIRECTED THERAPY; INTENSIVE INSULIN THERAPY; VENOUS OXYGEN-SATURATION; EARLY LACTATE CLEARANCE; CRITICALLY-ILL; SEVERE SEPSIS; ANTIMICROBIAL THERAPY; HYDROXYETHYL STARCH; FLUID RESUSCITATION; SURVIVING SEPSIS;
D O I
10.3949/ccjm.80a.12002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our understanding of the pathophysiology and treatment of sepsis has advanced over the last decade, and evidence-based protocols have improved its outcomes. Here, we review its management in the first hours and afterward, including topics of ongoing study and debate.
引用
收藏
页码:165 / 174
页数:10
相关论文
共 70 条
[1]   Coagulation in sepsis [J].
Amaral, A ;
Opal, SM ;
Vincent, JL .
INTENSIVE CARE MEDICINE, 2004, 30 (06) :1032-1040
[2]   Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].
Angus, DC ;
Linde-Zwirble, WT ;
Lidicker, J ;
Clermont, G ;
Carcillo, J ;
Pinsky, MR .
CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310
[3]   Current epidemiology of septic shock - The CUB-Rea network [J].
Annane, D ;
Aegerter, P ;
Jars-Guincestre, MC ;
Guidet, B .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (02) :165-172
[4]   Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock [J].
Annane, D ;
Sébille, V ;
Charpentier, C ;
Bollaert, PE ;
François, B ;
Korach, JM ;
Capellier, G ;
Cohen, Y ;
Azoulay, E ;
Troché, G ;
Chaumet-Riffaut, P ;
Bellissant, E .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (07) :862-871
[5]   Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock:: a randomised trial [J].
Annane, Djillali ;
Vignon, Philippe ;
Renault, Alain ;
Bollaert, Pierre-Edouard ;
Charpentier, Claire ;
Martin, Claude ;
Troche, Gilles ;
Ricard, Jean-Damien ;
Nitenberg, Gerard ;
Papazian, Laurent ;
Azoulay, Elie ;
Bellissant, Eric .
LANCET, 2007, 370 (9588) :676-684
[6]   MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS [J].
Arnold, Ryan C. ;
Shapiro, Nathan I. ;
Jones, Alan E. ;
Schorr, Christa ;
Pope, Jennifer ;
Casner, Elisabeth ;
Parrillo, Joseph E. ;
Dellinger, R. Phillip ;
Trzeciak, Stephen .
SHOCK, 2009, 32 (01) :35-39
[7]   HIGH SERUM PROCALCITONIN CONCENTRATIONS IN PATIENTS WITH SEPSIS AND INFECTION [J].
ASSICOT, M ;
GENDREL, D ;
CARSIN, H ;
RAYMOND, J ;
GUILBAUD, J ;
BOHUON, C .
LANCET, 1993, 341 (8844) :515-518
[8]   Effect of corticosteroids on arginine vasopressin-containing vasopressor therapy for septic shock: a case control study [J].
Bauer, Seth R. ;
Lam, Simon W. ;
Cha, Stephen S. ;
Oyen, Lance J. .
JOURNAL OF CRITICAL CARE, 2008, 23 (04) :500-506
[9]   Efficacy and safety of recombinant human activated protein C for severe sepsis. [J].
Bernard, GR ;
Vincent, JL ;
Laterre, P ;
LaRosa, SP ;
Dhainaut, JF ;
Lopez-Rodriguez, A ;
Steingrub, JS ;
Garber, GE ;
Helterbrand, JD ;
Ely, EW ;
Fisher, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :699-709
[10]   Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial [J].
Bouadma, Lila ;
Luyt, Charles-Edouard ;
Tubach, Florence ;
Cracco, Christophe ;
Alvarez, Antonio ;
Schwebel, Carole ;
Schortgen, Frederique ;
Lasocki, Sigismond ;
Veber, Benoit ;
Dehoux, Monique ;
Bernard, Maguy ;
Pasquet, Blandine ;
Regnier, Bernard ;
Brun-Buisson, Christian ;
Chastre, Jean ;
Wolff, Michel .
LANCET, 2010, 375 (9713) :463-474