共 30 条
Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23
被引:43
作者:

Cash, Jenna L.
论文数: 0 引用数: 0
h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

Bena, Stefania
论文数: 0 引用数: 0
h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

Headland, Sarah E.
论文数: 0 引用数: 0
h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

McArthur, Simon
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h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

Brancaleone, Vincenzo
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h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

Perretti, Mauro
论文数: 0 引用数: 0
h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England
机构:
[1] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England
基金:
英国惠康基金;
关键词:
chemerin peptide;
inflammation;
intravital microscopy;
neutrophil;
resolution;
NECROSIS-FACTOR-ALPHA;
LEUKOCYTE ADHESION;
L-SELECTIN;
INTEGRIN ACTIVATION;
SRC KINASES;
IMMUNITY;
RECEPTOR;
CELLS;
P38;
D O I:
10.1038/embor.2013.138
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Neutrophil activation and adhesion must be tightly controlled to prevent complications associated with excessive inflammatory responses. The role of the anti-inflammatory peptide chemerin15 (C15) and the receptor ChemR23 in neutrophil physiology is unknown. Here, we report that ChemR23 is expressed in neutrophil granules and rapidly upregulated upon neutrophil activation. C15 inhibits integrin activation and clustering, reducing neutrophil adhesion and chemotaxis in vitro. In the inflamed microvasculature, C15 rapidly modulates neutrophil physiology inducing adherent cell detachment from the inflamed endothelium, while reducing neutrophil recruitment and heart damage in a murine myocardial infarction model. These effects are mediated through ChemR23. We identify the C15/ChemR23 pathway as a new regulator and thus therapeutic target in neutrophil-driven pathologies.
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收藏
页码:999 / 1007
页数:9
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