LigSearch: a knowledge-based web server to identify likely ligands for a protein target

被引：1

作者：

de Beer, Tjaart A. P. ^{[1
]}

Laskowski, Roman A. ^{[1
]}

Duban, Mark-Eugene ^{[2
]}

Chan, A. W. Edith ^{[3
]}

Anderson, Wayne F. ^{[2
]}

Thornton, Janet M. ^{[1
]}

机构：

[1] EBI, EMBL, Cambridge CB10 1SD, England

[2] Northwestern Univ, Ctr Struct Genom Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA

[3] UCL, Biol & Med Chem Grp, Wolfson Inst Biomed Res, London WC1E 6BT, England

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2013年 / 69卷

基金：

美国国家卫生研究院;

关键词：

DATABASE; TOOL;

D O I：

10.1107/S0907444913022294

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.

引用

页码：2395 / 2402

页数：8

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