Neutralization of Zika virus by E protein domain III-Specific human monoclonal antibody

被引：8
作者：
Kim, Sang Il [1 ,2 ]
Kim, Sujeong [1 ,3 ]
Shim, Jung Min [4 ]
Lee, Hyo Jung [4 ]
Chang, So Young [5 ]
Park, Seoryeong [1 ,2 ]
Min, Ji-Young [5 ]
Park, Wan Beom [6 ]
Oh, Myoung-don [6 ]
Kim, Seungtaek [4 ]
Chung, Junho [1 ,2 ,3 ]
机构：
[1] Seoul Natl Univ, Coll Med, Dept Biochem & Mol Biol, Seoul 03080, South Korea
[2] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul 03080, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul 03080, South Korea
[4] Inst Pasteur Korea, Zoonot Virus Lab, Gyeonggi Do 13488, South Korea
[5] Inst Pasteur Korea, Resp Virus Lab, Gyeonggi Do 13488, South Korea
[6] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 03080, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 545卷
基金：
新加坡国家研究基金会;
关键词：
Zika virus; Neutralizing antibody; Microcephaly; Antibody-dependent enhancement; Guillain-Barre syndrome; DENGUE VIRUS; BISPECIFIC ANTIBODY; CROSS-REACTIVITY; INFECTION; REPLICATION; ENHANCEMENT;
D O I：
10.1016/j.bbrc.2021.01.075
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Zika virus (ZIKV) infection in both infants and adults is associated with neurological complications including, but not limited to, microcephaly and Guillain-Barre syndrome. Antibody therapy can be effective against virus infection. We isolated ZIKV envelope domain III-specific neutralizing antibodies (nAbs) from two convalescent patients with ZIKV infection. One antibody, 2F-8, exhibited potent in vitro neutralizing activity against Asian and American strains of ZIKV. To prevent Fc gamma R-mediated antibody dependent enhancement, we prepared IgG1 with LALA variation. A single dose of 2F-8 in the context of IgG1 or IgG1-LALA prior to or post lethal ZIKV challenge conferred complete protection in mice. (C) 2021 The Authors. Published by Elsevier Inc.
引用
收藏
页码：33 / 39
页数：7
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