Advanced glycation end products and soluble receptor as markers of oxidative stress in children on hemodialysis

被引：12

作者：

El-Saeed, Gamila S. M. ^{[1
]}

Fadel, Fatina ^{[2
]}

Elshamaa, Manal F. ^{[3
]}

Galal, Rasha E. E. ^{[2
]}

Elghoroury, Eman A. ^{[4
]}

Nasr, Soha A. ^{[4
]}

Thabet, Eman H. ^{[4
]}

Abdelrahman, Safaa M. ^{[4
]}

机构：

[1] Natl Res Ctr, Med Biochem, Cairo 12622, Egypt

[2] Cairo Univ, Fac Med, Dept Pediat, Cairo, Egypt

[3] Natl Res Ctr, Dept Pediat, Cairo 12622, Egypt

[4] Natl Res Ctr, Dept Clin & Chem Pathol, 33 El Buhus St, Cairo 12622, Egypt

来源：

RENAL FAILURE | 2015年 / 37卷 / 09期

关键词：

Advanced glycation end products; chronic renal failure in children; hemodialysis; markers of oxidative stress; soluble receptor AGE; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR RISK-FACTORS; STAGE RENAL-DISEASE; C-REACTIVE PROTEIN; DIABETIC-NEPHROPATHY; ASYMPTOMATIC PATIENTS; DIETARY GLYCOTOXINS; PLASMA PENTOSIDINE; TOTAL HOMOCYSTEINE; SERUM-LEVELS;

D O I：

10.3109/0886022X.2015.1077317

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Advanced glycation end products (AGEs) have biological properties that may contribute to the mortality of children on hemodialysis (HD). This study examines the relationship of LMW fluorescence AGEs, oxidized LDL (ox-LDL), soluble receptor AGE (sRAGE) as markers of oxidative stress in children with end stage renal disease (ESRD) undergoing HD. Method: Thirty children with ESRD undergoing HD, and 30 healthy, age- and sex-matched children were included. Serum levels of LMW fluorescence AGEs, sRAGE, oxidized LDL (ox-LDL), pre- and post-dialysis urea, high-sensitivity C-reactive protein (hs-CRP), hemoglobin (Hb) and serum albumin (ALB), were measured. Results: Abnormal serum inflammatory changes: elevated levels of LMW AGEs, sRAGE, oxLDL, CRP and urea were exhibited in HD children compared with healthy controls; more so in anemic when compared to non-anemic patients. Significant positive correlation was found between serum levels of AGEs and sRAGE. Conclusion: The low molecular weight form of AGEs is associated with oxidative stress in children receiving chronic HD, and may be important in the mechanisms leading to atherosclerosis and inflammation in such patients. LMW AGEs levels showed a negative correlation with sRAGE and both exhibit a significant negative relation to seum urea.

引用

页码：1452 / 1456

页数：5

共 43 条

[1] Circulating soluble receptor of advanced glycation end product inversely correlates with atherosclerosis in patients with chronic kidney disease [J].