Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review

被引：11

作者：

Yousefifard, Mahmoud ^{[1
]}

Sarveazad, Arash ^{[2
]}

Babahajian, Asrin ^{[3
]}

Baikpour, Masoud ^{[4
]}

Shokraneh, Farhad ^{[5
]}

Vaccaro, Alexander R. ^{[6
]}

Harrop, James S. ^{[7
]}

Fehlings, Michael G. ^{[8
,9
,10
,11
]}

Hosseini, Mostafa ^{[12
]}

Rahimi-Movaghar, Vafa ^{[13
,14
]}

机构：

[1] Iran Univ Med Sci, Physiol Res Ctr, Fac Med, Tehran, Iran

[2] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran

[3] Kurdistan Univ Med Sci, Liver & Digest Res Ctr, Sanandaj, Iran

[4] Univ Tehran Med Sci, Dept Med, Tehran, Iran

[5] Univ Nottingham, Inst Mental Hlth, Cochrane Schizophrenia Grp, Nottingham, England

[6] Thomas Jefferson Univ, Dept Orthoped & Neurosurg, Rothman Inst, Philadelphia, PA 19107 USA

[7] Thomas Jefferson Univ, Dept Neurosurg, Philadelphia, PA 19107 USA

[8] Univ Hlth Network, Krembil Res Inst, Div Genet & Dev, Toronto, ON, Canada

[9] Univ Hlth Network, Toronto Western Hosp, Div Neurosurg, Toronto, ON, Canada

[10] Univ Toronto, Dept Surg, Toronto, ON, Canada

[11] Univ Toronto, Spine Program, Toronto, ON, Canada

[12] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Poursina Ave, Tehran, Iran

[13] Univ Tehran Med Sci, Sina Trauma & Surg Res Ctr, Tehran, Iran

[14] Univ Tehran Med Sci, Neurosci Inst, Imam Khomeini Hosp, Brain & Spinal Injuries Res Ctr BASIR, Tehran, Iran

来源：

JOURNAL OF NEUROCHEMISTRY | 2019年 / 149卷 / 03期

关键词：

biomarkers; prognostics value; spinal cord injuries; STRUCTURAL BIOMARKERS; CELL TRANSPLANTATION; EVOKED POTENTIALS; PNF-H; SEVERITY; EXPRESSION; REMISSION; INTERLEUKIN-10; RECOVERY; MARKER;

D O I：

10.1111/jnc.14637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It remains unclear whether biomarkers in the serum or CSF can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic or diagnostic value of serum and CSF biomarkers in assessing the severity of SCI and the outcome of patients. Two independent reviewers summarized the human studies retrieved from the electronic databases of Medline, Embase, Scopus and ISI Web of Science until April 2018. Seventeen studies were included (1065 patients aged 16-94years old). Although the findings of the included studies suggest that inflammatory and structural proteins may be useful in assessing the severity of SCI and prediction of neurological outcome, the level of evidence is generally low. Given limitations to the available evidence, further investigation in this field is required using large prospective data sets with rigorous analysis of sensitivity, specificity and prediction.

引用

页码：317 / 330

页数：14

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