International consensus criteria for the diagnosis of Raynaud's phenomenon

被引：143

作者：

Maverakis, Emanual ^{[1
,2
]}

Patel, Forum ^{[1
]}

Kronenberg, Daniel G. ^{[1
]}

Chung, Lorinda ^{[3
,4
]}

Fiorentino, David ^{[3
,4
,5
]}

Allanore, Yannick ^{[6
]}

Guiducci, Serena ^{[7
]}

Hesselstrand, Roger ^{[8
]}

Hummers, Laura K. ^{[9
]}

Duong, Chris ^{[1
]}

Kahaleh, Bashar ^{[10
]}

Macgregor, Alexander ^{[11
]}

Matucci-Cerinic, Marco ^{[12
]}

Wollheim, Frank A. ^{[8
]}

Mayes, Maureen D. ^{[13
]}

Gershwin, M. Eric ^{[14
]}

机构：

[1] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95816 USA

[2] Vet Affairs Northern Calif Hlth Care Syst, Dept Dermatol, Sacramento, CA 95655 USA

[3] Stanford Univ, Div Rheumatol & Immunol, Dept Internal Med & Dermatol, Palo Alto, CA 94305 USA

[4] Palo Alto VA Hosp, Palo Alto, CA 94305 USA

[5] Stanford Univ, Dept Dermatol, Redwood City, CA 94305 USA

[6] Paris Descartes Univ, Dept Rheumatol, Paris, France

[7] Univ Florence, Dept Rheumatol, Florence, Italy

[8] Lund Univ, Dept Rheumatol, Lund, Sweden

[9] Johns Hopkins Univ, Dept Med Rheumatol, Baltimore, MD 21287 USA

[10] Univ Toledo, Div Rheumatol, Dept Internal Med, Toledo, OH 43614 USA

[11] Univ E Anglia, Dept Rheumatol, Norwich NR4 7TJ, Norfolk, England

[12] Univ Florence, Dept Med & Rheumatol, Florence, Italy

[13] Univ Texas Houston, Div Rheumatol & Clin Immunogenet, Dept Internal Med, Houston, TX 77030 USA

[14] Univ Calif Davis, Div Rheumatol, Dept Internal Med, Davis, CA 95616 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2014年 / 48-49卷

关键词：

Raynaud's phenomenon; Primary Raynaud's; Secondary Raynaud's; Diagnostic criteria; DISTAL-DORSAL DIFFERENCE; DIGITAL BLOOD-PRESSURE; CAPILLAROSCOPY; SCLERODERMA; VIBRATION; FLOW;

D O I：

10.1016/j.jaut.2014.01.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vasoconstriction accompanied by changes in skin color is a normal physiologic response to cold. The distinction between this normal physiology and Raynaud's phenomenon (RP) has yet to be well characterized. In anticipation of the 9th International Congress on Autoimmunity, a panel of 12 RP experts from 9 different institutes and four different countries were assembled for a Delphi exercise to establish new diagnostic criteria for RP. Relevant investigators with highly cited manuscripts in Raynaud's-related research were identified using the Web of Science and invited to participate. Surveys at each stage were administered to participants via the on-line SurveyMonkey software tool. The participants evaluated the level of appropriateness of statements using a scale of 1 (extremely inappropriate) through 9 (extremely appropriate). In the second stage, panel participants were asked to rank rewritten items from the first round that were scored as "uncertain" for the diagnosis of RP, items with significant disagreement (Disagreement Index > 1), and new items suggested by the panel. Results were analyzed using the Interpercentile Range Adjusted for Symmetry (IPRAS) method. A 3-Step Approach to diagnose RP was then developed using items the panelists "agreed" were "appropriate" diagnostic criteria. In the final stage, the panel was presented with the newly developed diagnostic criteria and asked to rate them against previous models. Following the first two iterations of the Delphi exercise, the panel of 12 experts agreed that 36 of the items were "appropriate", 12 items had "uncertain" appropriateness, and 13 items were "inappropriate" to use in the diagnostic criteria of RP. Using an expert committee, we developed a 3-Step Approach for the diagnosis of RP and 5 additional criteria for the diagnosis of primary RP. The committee came to an agreement that the proposed criteria were "appropriate and accurate" for use by physicians to diagnose patients with RP. Published by Elsevier Ltd.

引用

页码：60 / 65

页数：6

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