A simple and efficient one-pot synthesis of novel benzimidazo[1,2-a]-chromeno[4,3-d] pyrimidinones catalyzed by [Et3NH][HSO4]

被引：0
作者：
Prasoona, G. [1 ,2 ]
Kishore, B. [1 ]
Brahmeshwari, G. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India
[2] Govt Degree Coll, Narsampet 506132, Warangal Rural, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2020年 / 59卷 / 09期
关键词：
Multi-component synthesis; benzimidazo[1,2-a]chromeno[4,3-d]pyrimidinones; polyheterocycles; triethyl ammonium hydrogen sulphate [TEAHS; solvent-free conditions; MULTICOMPONENT SYNTHESIS; DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient one-pot synthesis of novel polyheterocyclic benzimidazo[1,2-a]-chromeno[4,3-d]pyrimidinones 4 via a three-component condensation of 2-aminobenzimidazole 1, aromatic aldehydes 2 and 4-hydroxy coumarin 3 catalyzed by Bronsted acid ionic liquid triethyl ammonium hydrogen sulphate [Et3NH][HSO4] under solvent-free conditions is reported. The main advantages of this protocol are short reaction time, easy work-up, operational simplicity, and excellent yields with high purity, without intervention of chromatography.
引用
收藏
页码：1418 / 1424
页数：7
相关论文
共 28 条
  • [1] A parallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis
    AlMuhaimeed, H
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1997, 25 (04) : 175 - 181
  • [2] Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine
    Anand, Devireddy
    Yadav, Pawan Kumar
    Patel, Om P. S.
    Parmar, Naveen
    Maurya, Rahul K.
    Vishwakarma, Preeti
    Raju, Kanumuri S. R.
    Taneja, Isha
    Wahajuddin, M.
    Kar, Susanta
    Yadav, Prem P.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (03) : 1041 - 1059
  • [3] Asobo PF, 2001, J CHEM SOC PERK T 1, P457
  • [4] Balzarini J, 2002, HELV CHIM ACTA, V85, P2961, DOI 10.1002/1522-2675(200209)85:9<2961::AID-HLCA2961>3.0.CO
  • [5] 2-R
  • [6] Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones
    Bruno, O
    Brullo, C
    Schenone, S
    Bondavalli, F
    Ranise, A
    Tognolini, M
    Impicciatore, M
    Ballabeni, V
    Barocelli, E
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (01) : 121 - 130
  • [7] Chemistry and biological activity of natural and synthetic prenyloxycoumarins
    Curini, M
    Cravotto, G
    Epifano, F
    Giannone, G
    [J]. CURRENT MEDICINAL CHEMISTRY, 2006, 13 (02) : 199 - 222
  • [8] Synthesis of a group of 1H-benzimidazoles and their screening for antiinflammatory activity
    Evans, D
    Hicks, TA
    Williamson, WRN
    Dawson, W
    Meacock, SCR
    Kitchen, EA
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (7-8) : 635 - 642
  • [9] Synthesis and antiproliferative activity of some benzimidazole-4,7-dione derivatives
    Garuti, L
    Roberti, M
    Malagoli, M
    Rossi, T
    Castelli, M
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (19) : 2193 - 2195
  • [10] Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors
    Huang, Hui
    Hutta, Daniel A.
    Hu, Huaping
    DesJarlais, Renee L.
    Schubert, Carsten
    Petrounia, Ioanna P.
    Chaikin, Margery A.
    Manthey, Carl L.
    Player, Mark R.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (07) : 2355 - 2361
123