Malaria, primigravidae, and antibodies: knowledge gained and future perspectives

被引：50

作者：

Ataide, Ricardo ^{[1
]}

Mayor, Alfredo ^{[2
,3
]}

Rogerson, Stephen J. ^{[1
]}

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3050, Australia

[2] Univ Barcelona, Hosp Clin, Barcelona Ctr Int Hlth Res CRESIB, Barcelona, Spain

[3] CISM, Manhica, Mozambique

来源：

TRENDS IN PARASITOLOGY | 2014年 / 30卷 / 02期

关键词：

malaria; primigravidae; antibodies; VAR2CSA; pregnancy; epidemiology; surveillance; serology; FALCIPARUM-INFECTED ERYTHROCYTES; VARIANT SURFACE-ANTIGENS; CHONDROITIN SULFATE-A; PREGNANCY-ASSOCIATED MALARIA; ADHERENT PLASMODIUM-FALCIPARUM; BLOOD-STAGE ANTIGENS; PLACENTAL MALARIA; IMMUNOGLOBULIN-G; CAMEROONIAN WOMEN; IMMUNE-RESPONSES;

D O I：

10.1016/j.pt.2013.12.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Pregnant women have an increased risk of malaria infection, independent of previously acquired immunity. Women in their first pregnancy and children under the age of five are the primary victims of malaria worldwide. Pregnant women develop antibodies against placentaadhesive parasites in a parity-dependent manner. Various efforts to understand the targets, quality, and quantity of this antibody response could aid the design of an effective vaccine against placental malaria. This review focuses on the research that has led to the current understanding of the antibody response that primigravidae (PG) acquire to Plasmodium falciparum malaria and draws from this knowledge to suggest serology and PG as sentinels for malaria transmission.

引用

页码：85 / 94

页数：10

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