Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses

被引：10

作者：

Dangaj, Denarda ^{[1
]}

Scholler, Nathalie ^{[2
]}

机构：

[1] Univ Lausanne, Ludwig Canc Res Ctr, Dept Oncol, Lausanne, Switzerland

[2] SRI Int, Ctr Canc & Metab, Menlo Pk, CA 94025 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 08期

关键词：

ovarian cancer; B7-H4; recombinant antibodies; cell surface expression; targeting; immunotherapy; HUMAN OVARIAN-CARCINOMA; EXPRESSION; CANCER;

D O I：

10.4161/onci.25913

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

B7-H4 inhibits T-cell activation and is widely expressed by solid neoplasms. We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of tumor-specific T cells. Thus, antibodies targeting the B7-H4 pathways may extend the survival of cancer patients by restoring T cell-mediated antitumor responses. © 2013 Landes Bioscience.

引用

页数：3

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