Effects of Smart Advanced Life Support protocol implementation including CPR coaching during out-of-hospital cardiac arrest

Purpose: The aim of this study was to compare out-of-hospital cardiac arrest (OHCA) outcomes before and after implementation of Smart Advanced Life Support (SALS) protocol incorporating changes in cardiopulmonary re-suscitation (CPR) assistance and coaching by physicians via real-time video calls. Methods: A prospective before-and-after multi-regional observational study was conducted between January 2014 and December 2018. In January 2016, emergency medical service (EMS) providers adopted an integrated CPR coaching by physicians via real-time video call via SALS to treat patients with OHCA focusing on high-quality cardiopulmonary resuscitation. Propensity score matching was performed to match patients. Patients' outcomes using conventional protocol were then compared with those of patients using the SALS protocol. Results: Among 26,349 OHCA cases, 2351 patients and 7261 patients were enrolled during the pre-intervention and the post-intervention periods, respectively. Multivariate analysis showed that SALS was independently asso-ciated with favorable neurological outcomes [odds ratio (OR): 2.20; 95% confidence interval (CI): 1.62-2.99]. A total of 2096 patients were propensity score-matched and the two groups were well balanced. In the matched cohort, the use of SALS protocol was still associated with increased prehospital return of spontaneous circulation (ROSC) (OR: 3.83, 95% CI: 2.80-5.26), survival to discharge (OR: 1.68; 95% CI: 1.20-2.34), and favorable neuro-logical outcomes (OR: 1.83; 95% CI: 1.19-2.82). Conclusion: A multidisciplinary SALS protocol for the resuscitation of patients with OHCA was associated with in-creased prehospital ROSC, survival to discharge, and good neurologic outcomes compared with traditional resus-citation protocol. (c) 2022 Elsevier Inc. All rights reserved.