A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

被引：74
作者：
Bychek, Roman [1 ]
Mykhailiuk, Pavel K. [1 ]
机构：
[1] Enamine Ltd, Chervonotkatska 60, UA-02094 Kiev, Ukraine
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 29期
基金：
欧洲研究理事会;
关键词：
Bicyclo[1; 1; 0]butane; 1]pentane; Bioisosteres; Fluorine; CHEMISTRY; PEPTIDE; DESIGN;
D O I：
10.1002/anie.202205103
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.
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页数：7
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