A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

被引：74

作者：

Bychek, Roman ^{[1
]}

Mykhailiuk, Pavel K. ^{[1
]}

机构：

[1] Enamine Ltd, Chervonotkatska 60, UA-02094 Kiev, Ukraine

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 29期

基金：

欧洲研究理事会;

关键词：

Bicyclo[1; 1; 0]butane; 1]pentane; Bioisosteres; Fluorine; CHEMISTRY; PEPTIDE; DESIGN;

D O I：

10.1002/anie.202205103

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

引用

页数：7

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