The battle of the sexes

被引：185
作者：
Capel, B [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
来源：
MECHANISMS OF DEVELOPMENT | 2000年 / 92卷 / 01期
基金：
美国国家卫生研究院;
关键词：
sex determination; Sry; sertoli cell; leydig cell; peritubular myoid cell; cell migration; vascular formation; proliferation; Sox9; Mmis; Wtl; Daxl; Sfl; M33; ATRX; Wnt4; XH2; Dmrt1; mouse; chicken; alligator;
D O I：
10.1016/S0925-4773(99)00327-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The sex determining gene, Sry, determines the sex of the organism by initiating development of a testis rather than an ovary from the cells of the bipotential gonad. In the 10 years since the discovery of Sry, new genes and cellular pathways that operate in the establishment of the gonadal primordium and the initiation of testis development have been discovered. Experiments defining mechanisms downstream of Sry. are providing clear examples of how a regulatory transcription factor initiates cellular processes including proliferation and cell migration, which in turn influence architectural patterning, fate commitment, and differentiation of cells within an organ. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：89 / 103
页数：15
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