Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design

被引：452
作者：
Ladbury, JE
机构：
[1] Dept. of Biochem. and Molec. Biology, University College London, London W1P 8BT
来源：
CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 12期
关键词：
D O I：
10.1016/S1074-5521(96)90164-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent data have highlighted the enigmatic role that water plays in biomolecular complexes. Water at the interface of a complex can increase the promiscuity of an interaction, yet it can also provide increased specificity and affinity. The ability to engineer water-binding sites into the interface between a drug and its target might prove useful in drug design. (C) Current Biology Ltd.
引用
收藏
页码：973 / 980
页数：8
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