A fluorescent probe for specific detection of cysteine in the lipid dense region of cells

被引：53

作者：

Ali, Firoj ^{[1
]}

Anila, H. A. ^{[1
]}

Taye, Nandaraj ^{[2
]}

Gonnade, Rajesh G. ^{[3
]}

Chattopadhyay, Samit ^{[2
]}

Das, Amitava ^{[1
]}

机构：

[1] CSIR, Natl Chem Lab, Div Organ Chem, Pune 411007, Maharashtra, India

[2] Natl Ctr Cell Sci, Chromatin & Dis Biol Lab, Pune 411007, Maharashtra, India

[3] CSIR, Natl Chem Lab, Ctr Mat Characterizat, Pune 411007, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 95期

关键词：

DISULFIDE BOND FORMATION; GLUTATHIONE; CHEMODOSIMETER; HOMOCYSTEINE; REAGENTS; THIOLS; STATE; ASSAY; DYE;

D O I：

10.1039/c5cc07450a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new cysteine (Cys) specific chemodosimetric reagent (ER-F) is used in imaging of endogenous Cys localized in the lipid dense region of the live Hct116 cells and the release of Cys within HepG2 cells from a drug following a biochemical transformation. A silica surface, modified with ER-F, could be used for quantitative estimation of Cys present in aqueous solution (pH 7.2) and in a human blood plasma (HBP).

引用

页码：16932 / 16935

页数：4

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