Investigation of wear and wear particles from a UHMWPE/multi-walled carbon nanotube nanocomposite for total joint replacements

被引：43

作者：

Suner, Silvia ^{[1
]}

Bladen, Catherine L. ^{[2
]}

Gowland, Nicholas ^{[2
]}

Tipper, Joanne L. ^{[2
]}

Emami, Nazanin ^{[1
]}

机构：

[1] Lulea Univ Technol, Dept Engn Sci & Math, SE-97187 Lulea, Sweden

[2] Inst Med & Biol Engn, Leeds, W Yorkshire, England

来源：

WEAR | 2014年 / 317卷 / 1-2期

关键词：

Biotribology; Wear debris; Ultra high molecular weight polyethylene; Nanocomposites; Biocompatibility; Joint prostheses; MOLECULAR-WEIGHT POLYETHYLENE; FUNCTIONAL BIOLOGICAL-ACTIVITY; IN-VITRO; TRIBOLOGICAL BEHAVIOR; MACROPHAGES; SIZE; CHALLENGE; DEBRIS;

D O I：

10.1016/j.wear.2014.05.014

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

Ultra high molecular weight polyethylene (UHMWPE) has been extensively used as a bearing surface in joint prostheses. However, wear debris generated from this material has been associated with osteolysis and implant loosening. Alternative materials, such as polymer composites, have been investigated due to their exceptional mechanical properties. The goal of the present work was to investigate the wear rate, size and volume distributions, bioactivity and biocompatibility of the wear debris generated from a UHMWPE/Multi-walled carbon nanotube (MWCNT) nanocomposite material compared with conventional UHMWPE. The results showed that the addition of MWCNTs led to a significant reduction in wear rate. Specific biological activity and functional biological activity predictions showed that wear particles from the UHMWPE/MWCNT nanocomposite had a reduced osteolytic potential compared to those produced from the conventional polyethylene. In addition, clinically relevant UHMWPE/MWCNT wear particles did not show any adverse effects on the L929 fibroblast cell viability at any of the concentrations tested over time. These findings suggest that UHMWPE/MWCNT nanocomposites represent an attractive alternative for orthopaedic applications. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：163 / 169

页数：7

共 36 条

[1]

[Anonymous], P T AAOS M SCI EXH S

[2]

[Anonymous], 2013, CARBON NANOFILLER RE

[3] Wear of ceramic-on-carbon fiber-reinforced poly-ether ether ketone hip replacements [J].

Brockett, Claire L. ;

John, Gemma ;

Williams, Sophie ;

Jin, Zhongmin ;

Isaac, Graham H. ;

Fisher, John .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2012, 100B (06) :1459-1465

[4] INCORPORATION OF CARBON NANOTUBES INTO ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE BY HIGH ENERGY BALL MILLING [J].

Campo, N. ;

Visco, A. M. .

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION, 2010, 15 (07) :438-449

[5] Five-year experience with Crossfire® highly cross-linked polyethylene [J].

D'Antonio, JA ;

Manley, MT ;

Capello, WN ;

Bierbaum, BE ;

Ramakrishnan, R ;

Naughton, M ;

Sutton, K .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2005, (441) :143-150

[6] Fundamental aspects and recent progress on wear/scratch damage in polymer nanocomposites [J].

Dasari, Aravind ;

Yu, Zhong-Zhen ;

Mai, Yiu-Wing .

MATERIALS SCIENCE & ENGINEERING R-REPORTS, 2009, 63 (02) :31-80

[7]

del Prever EMB, 2009, J ORTHOP TRAUMATOL, V10, P1, DOI [10.1007/s10195-008-0038-y, 10.1007/s10195-008-00380-y]

[8] The basis for a second-generation highly cross-linked UHMWPE [J].

Dumbleton, John H. ;

D'Antonio, James A. ;

Manley, Michael T. ;

Capello, William N. ;

Wang, Aiguo .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2006, (453) :265-271

[9] Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses [J].

Endo, M ;

Tipper, JL ;

Barton, DC ;

Stone, MH ;

Ingham, E ;

Fisher, J .

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, 2002, 216 (H2) :111-122

[10] Wear, debris, and biologic activity of cross-linked polyethylene in the knee - Benefits and potential concerns [J].

Fisher, J ;

McEwen, HMJ ;

Tipper, JL ;

Galvin, AL ;

Ingram, J ;

Kamali, A ;

Stone, MH ;

Ingham, E .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2004, (428) :114-119

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