The first A-nor-hippuristanol and two novel 4,5-secosuberosanoids from the Gorgonian Isis hippuris

被引：44
作者：
Sheu, JH [1 ]
Chao, CH
Wang, GH
Hung, KC
Duh, CY
Chiang, MY
Wu, YC
Wu, CC
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan
[2] Hsing Kuo Univ, Ctr Gen Educ, Tainan 709, Taiwan
[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan
[4] Kaohsiung Med Univ, Sch Chem, Kaohsiung 807, Taiwan
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 34期
关键词：
Isis hippuris; coral; A-nor-22-epi-hippurin-2 alpha-carboxylic acid; isishippuric acid A; isishippuric acid B;
D O I：
10.1016/j.tetlet.2004.07.001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first A-nor-hippuristanol, A-nor-22-epi-hippurin-2alpha-carboxylic acid (1), and two 4,5-secosuberosane sesquiterpenoids, isishippuric acids A and B (2 and 3), have been isolated from the gorgonian coral Isis hippuris. Those structures were deduced by extensive I D and 2D NMR studies. The structure of I was further supported by a single crystal X-ray diffraction analysis. Isishippuric acid B has been shown to exhibit potent cytotoxicity toward a limited panel of cancer cells. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6413 / 6416
页数：4
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