Up-regulated expression of miR-155 in human colonic cancer

被引：28

作者：

Cao, Hongliang ^{[1
]}

Huang, Shaojun ^{[2
]}

Liu, Aihua ^{[3
]}

Chen, Zhidan ^{[1
]}

机构：

[1] Hubei Univ Arts & Sci, Affiliated Xiangyang Cent Hosp, Dept Gen Surg, 136 Jinzhou Rd, Xiangyang, Hubei, Peoples R China

[2] Hubei Univ Arts & Sci, Affiliated Xiangyang Cent Hosp, Dept Clin Lab, Xiangyang, Hubei, Peoples R China

[3] Hubei Univ Arts & Sci, Affiliated Xiangyang Cent Hosp, Dept Tumor, Xiangyang, Hubei, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2018年 / 14卷 / 03期

关键词：

Colonic cancer; micro RNA; miR-155; BREAST-CANCER; POOR-PROGNOSIS; MICRORNAS; PATTERNS; GROWTH; TUMORS; GENE;

D O I：

10.4103/0973-1482.175432

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: The aim of this study is to investigate the expression of miR-155 in colonic cancer tissue and to assess the potential predictive value of miR-155 in colonic cancer patients. Materials and Methods: From March to September of 2011, we included 57 patients with primary colonic cancer who underwent curative surgical resection. Total RNAs were extracted from colonic cancer tissues and adjacent normal tissues. Then the expression of miR-155 in colonic cancer and paracancerous tissues was investigated using real time quantitative reverse transcription-polymerase chain reaction. And the relationship between miR-155 expression level and the clinical, pathological parameters of colonic cancer was analyzed. Results: The relative expression level of miR-155 in colonic cancer tissues was significantly higher than that in paracancerous tissues and related to tumor-node-metastasis staging, tumor invasion, metastasis, and differentiation. Conclusion: The expression of miR-155 is up-regulated in colonic cancer tissues. MiR-155 may acts as proto-oncogenes involved in carcinogenesis, development, and invasion of colon cancer making it a potential target for gene therapy of colon cancer.

引用

页码：604 / 607

页数：4

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